Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | LSS | P48449 | 4/20 | 0.49 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 2/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.44 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16508752 | 0.86 | HTR2A (0.48) | HTR2AHTR2CLSSTRPV4LMNA | |
| SCHEMBL28035458 | 0.84 | HTT (0.63) | HTR2AHTR2CLMNAHTTSMN1; SMN2 | |
| SCHEMBL16508863 | 0.83 | LSS (0.48) | HTR2AHTR2CLSSTRPV4LMNA | |
| SCHEMBL13465623 | 0.81 | TRPV4 (0.67) | HTR2AHTR2CTRPV4LMNAHTT | |
| SCHEMBL10263936 | 0.79 | KMT2A (0.57) | LMNAHTTSMN1; SMN2KDM4EGAA | |
| SCHEMBL12571055 | 0.79 | HDAC4 (0.48) | HTR2AHTR2CLSSTRPV4LMNA | |
| SCHEMBL6018716 | 0.79 | LSS (0.58) | HTR2AHTR2CLSSTRPV4 | |
| SCHEMBL6018713 | 0.79 | LSS (0.58) | HTR2AHTR2CLSSTRPV4 | |
| SCHEMBL28035878 | 0.78 | HTR2A (0.53) | HTR2AHTR2CLSSTRPV4MMP3 | |
| SCHEMBL13434084 | 0.77 | MAPT (0.57) | LMNAHTTSMN1; SMN2KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106986857-B | Trk inhibiting compound | 小野药品工业株式会社 | 2019-07-05 | — | — | CN | disclosed |
| CN-106986857-A | Trk inhibiting compounds | 小野药品工业株式会社 | 2017-07-28 | — | — | CN | disclosed |
| CN-106928197-A | Trk inhibiting compounds | 小野药品工业株式会社 | 2017-07-07 | — | — | CN | disclosed |
| CN-104995172-B | Trk inhibiting compounds | 小野药品工业株式会社 | 2017-05-31 | — | — | CN | disclosed |