Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 7/20 | 0.63 |
| ▸ | LMNA | P02545 | 6/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.54 |
| ▸ | MMP3 | P08254 | 1/20 | 0.54 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.51 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.51 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.51 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | XBP1 | P17861 | 1/20 | 0.50 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27312349 | 0.88 | HTT (0.56) | HTTLMNASMN1; SMN2NPSR1GAA | |
| SCHEMBL28141663 | 0.84 | HTR2A (0.50) | HTTLMNASMN1; SMN2NPSR1GAA | |
| SCHEMBL14349177 | 0.83 | HTT (0.66) | HTTLMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL4927115 | 0.83 | HTT (0.56) | HTTLMNASMN1; SMN2NPSR1GAA | |
| SCHEMBL13465623 | 0.79 | TRPV4 (0.67) | HTTLMNASMN1; SMN2KDM4EMAPT | |
| SCHEMBL3246445 | 0.79 | ALDH1A1 (0.73) | HTTLMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL28340795 | 0.78 | KEAP1 (0.49) | HTTLMNASMN1; SMN2NPSR1GAA | |
| SCHEMBL27312342 | 0.78 | HTT (0.50) | HTTLMNASMN1; SMN2NPSR1GAA | |
| SCHEMBL16508752 | 0.77 | HTR2A (0.48) | HTTLMNASMN1; SMN2NPSR1GAA | |
| SCHEMBL23057256 | 0.76 | LMNA (0.73) | HTTLMNASMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106986857-B | Trk inhibiting compound | 小野药品工业株式会社 | 2019-07-05 | — | — | CN | disclosed |
| CN-106986857-A | Trk inhibiting compounds | 小野药品工业株式会社 | 2017-07-28 | — | — | CN | disclosed |
| CN-106928197-A | Trk inhibiting compounds | 小野药品工业株式会社 | 2017-07-07 | — | — | CN | disclosed |
| CN-104995172-B | Trk inhibiting compounds | 小野药品工业株式会社 | 2017-05-31 | — | — | CN | disclosed |
| CN-104995172-A | Trk inhibiting compounds | ONO PHARMACEUTICAL CO | 2015-10-21 | — | — | CN | disclosed |