Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.39 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2814433 | 1.00 | PROKR1 (0.39) | PROKR1KLK5SMN1; SMN2CNR2ALDH1A1 | |
| SCHEMBL7899697 | 0.91 | PROKR1 (0.39) | PROKR1KLK5CNR2ALDH1A1ACE | |
| SCHEMBL7891211 | 0.91 | PROKR1 (0.42) | PROKR1KLK5CNR2ALDH1A1ACE | |
| SCHEMBL7902566 | 0.90 | PROKR1 (0.38) | PROKR1KLK5CNR2ACEHRH2 | |
| SCHEMBL7897770 | 0.88 | PROKR1 (0.37) | PROKR1KLK5CNR2ACEHRH2 | |
| SCHEMBL2788344 | 0.88 | PROKR1 (0.38) | PROKR1KLK5CNR2ALDH1A1ACE | |
| SCHEMBL7903380 | 0.87 | PROKR1 (0.39) | PROKR1KLK5CNR2ACEHRH2 | |
| SCHEMBL2814775 | 0.87 | PROKR1 (0.37) | PROKR1KLK5CNR2ACEHRH2 | |
| SCHEMBL7893430 | 0.87 | USP30 (0.36) | PROKR1KLK5CNR2ACEHRH2 | |
| SCHEMBL2814776 | 0.87 | PROKR1 (0.37) | PROKR1KLK5CNR2ACEHRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |