Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 6/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2219633 | 0.78 | CYP2A6 (0.52) | TDO2CYP2A6CYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL12264112 | 0.77 | CYP11B1 (0.42) | TDO2CYP2A6CYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL12509851 | 0.77 | CYP2A6 (0.52) | CYP2A6CYP3A4ALDH1A1CYP1A2MKNK1 | |
| SCHEMBL2591471 | 0.76 | CYP2A6 (0.50) | TDO2CYP2A6CYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL2219704 | 0.72 | CYP2A6 (0.47) | TDO2CYP2A6CYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL19054762 | 0.70 | CYP2A6 (0.56) | TDO2CYP2A6CYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL1956794 | 0.67 | CYP2A6 (0.52) | TDO2CYP2A6CYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL3068958 | 0.67 | HSP90AA1 (0.56) | CYP2A6CYP3A4ALDH1A1CYP1A2MKNK1 | |
| SCHEMBL12264113 | 0.67 | CYP2A6 (0.52) | CYP2A6CYP3A4ALDH1A1CYP1A2MKNK1 | |
| SCHEMBL29450604 | 0.66 | ALDH1A1 (0.58) | TDO2CYP2A6CYP3A4ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106892916-A | The indazole inhibitors and its treatment use of WNT signal paths | 萨穆梅德有限公司 | 2017-06-27 | — | — | CN | disclosed |
| CN-105037355-B | The indazole inhibitors and its therapeutical uses of Wnt signal transduction paths | 萨穆梅德有限公司 | 2017-06-06 | — | — | CN | disclosed |