SCHEMBL2219633

SCHEMBL2219633

Nc1cncc(-c2cccnc2)c1N

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 8/20 0.52
CYP3A4 P08684 3/20 0.52
ALDH1A1 P00352 2/20 0.52
CYP1A2 P05177 1/20 0.52
TDO2 P48775 1/20 0.51
MKNK1 Q9BUB5 4/20 0.47
MKNK2 Q9HBH9 4/20 0.47
MEN1 O00255 1/20 0.47
PSIP1 O75475 1/20 0.47
AXL P30530 1/20 0.47
CYP2E1 P05181 2/20 0.46
CYP2D6 P10635 2/20 0.46
CYP2C9 P11712 2/20 0.46
CYP2B6 P20813 2/20 0.46
CYP2C19 P33261 2/20 0.46
KDM4E B2RXH2 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
LMNA P02545 1/20 0.45
TP53 P04637 1/20 0.45
MAPT P10636 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22258410 0.82 ALDH1A1 (0.48) ALDH1A1TDO2MEN1KDM4ESMN1; SMN2
SCHEMBL1956794 0.81 CYP2A6 (0.52) CYP2A6CYP3A4ALDH1A1CYP1A2TDO2
SCHEMBL19054762 0.80 CYP2A6 (0.56) CYP2A6CYP3A4ALDH1A1CYP1A2TDO2
SCHEMBL15783990 0.80 CYP2A6 (0.56) CYP2A6CYP3A4ALDH1A1CYP1A2TDO2
Ammonia Solution, Strong SCHEMBL16035727 0.78 CYP2A6 (0.54) CYP2A6CYP3A4ALDH1A1CYP1A2TDO2
SCHEMBL2221297 0.78 MAPT (0.43) CYP2A6CYP3A4ALDH1A1CYP1A2MEN1
SCHEMBL28146113 0.78 TDO2 (0.45) CYP2A6CYP3A4ALDH1A1CYP1A2TDO2
SCHEMBL29450604 0.76 ALDH1A1 (0.58) CYP2A6CYP3A4ALDH1A1CYP1A2TDO2
SCHEMBL221510 0.76 ALDH1A1 (0.58) CYP2A6CYP3A4ALDH1A1CYP1A2TDO2
SCHEMBL2219704 0.75 CYP2A6 (0.47) CYP2A6CYP3A4ALDH1A1CYP1A2TDO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 205 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260116878-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF BIOSPLICE THERAPEUTICS INC (US) 2026-04-30 US disclosed
US-20240116927-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF MED-PATHWAYS II LIMITED (VG) 2024-04-11 US disclosed
US-11697649-B2 Indazole inhibitors of the Wnt signal pathway and therapeutic uses thereof BIOSPLICE THERAPEUTICS, INC. (US) 2023-07-11 US disclosed
US-11697649-B2 Indazole inhibitors of the Wnt signal pathway and therapeutic uses thereof BIOSPLICE THERAPEUTICS, INC. (US) 2023-07-11 US disclosed
US-11697649-B2 Indazole inhibitors of the Wnt signal pathway and therapeutic uses thereof BIOSPLICE THERAPEUTICS, INC. (US) 2023-07-11 US disclosed
US-20230013144-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF TENARX, INC. 2023-01-19 US disclosed
US-20230013144-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF TENARX, INC. 2023-01-19 US disclosed
EP-3915988-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF BioSplice Therapeutics, Inc. (US) 2021-12-01 EP disclosed
US-10947228-B2 Indazole inhibitors of the Wnt signal pathway and therapeutic uses thereof SAMUMED, LLC (US) 2021-03-16 US disclosed
US-10947228-B2 Indazole inhibitors of the Wnt signal pathway and therapeutic uses thereof SAMUMED, LLC (US) 2021-03-16 US disclosed
US-20110190290-A1 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF EPITHERIX, LLC (US) 2011-08-04 US disclosed
US-20110190290-A1 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF EPITHERIX, LLC (US) 2011-08-04 US disclosed
US-20110190290-A1 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF EPITHERIX, LLC (US) 2011-08-04 US disclosed
WO-2011084486-A1 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF EPITHERIX, LLC (US) 2011-07-14 WO disclosed
WO-2011084486-A1 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF EPITHERIX, LLC (US) 2011-07-14 WO disclosed
WO-2011019651-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF EPITHERIX, LLC (US) 2011-02-17 WO disclosed
US-20110034497-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF EPITHERIX, LLC (US) 2011-02-10 US disclosed
US-20110034497-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF EPITHERIX, LLC (US) 2011-02-10 US disclosed
US-20110034441-A1 INDAZOLES AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS AND THERAPEUTIC USES THEREOF EPITHERIX, LLC (US) 2011-02-10 US disclosed
US-20110034441-A1 INDAZOLES AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS AND THERAPEUTIC USES THEREOF EPITHERIX, LLC (US) 2011-02-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10947228-B2 Indazole inhibitors of the Wnt signal pathway and therapeutic uses thereof WNT1, WNT3, WNT3A CYP2A6 2099/4885CYP3A4 959/4885ALDH1A1 1414/4885
US-20110190290-A1 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF BRCA1, THPO, PDXK CYP2A6 311/4885CYP3A4 27/4885ALDH1A1 123/4885
US-11697649-B2 Indazole inhibitors of the Wnt signal pathway and therapeutic uses thereof WNT1, WNT3, WNT3A CYP2A6 2099/4885CYP3A4 959/4885ALDH1A1 1414/4885
US-20230013144-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF WNT1, WNT3, WNT3A CYP2A6 2099/4885CYP3A4 959/4885ALDH1A1 1414/4885
US-20110034497-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF WNT1, WNT3, WNT3A CYP2A6 2287/4885CYP3A4 1250/4885ALDH1A1 1282/4885
US-20240116927-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF WNT1, WNT3, WNT3A CYP2A6 2099/4885CYP3A4 959/4885ALDH1A1 1414/4885
US-20110034441-A1 INDAZOLES AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS AND THERAPEUTIC USES THEREOF WNT1, WNT3A, WNT3 CYP2A6 2541/4885CYP3A4 1447/4885ALDH1A1 1938/4885
US-20260116878-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF WNT1, WNT3, WNT3A CYP2A6 761/4885CYP3A4 1322/4885ALDH1A1 1879/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.