SCHEMBL28146972

SCHEMBL28146972

OC(=S)Nc1ccccc1NC(O)=S

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.48
TAS2R38 P59533 3/20 0.48
HSD17B10 Q99714 3/20 0.48
CYP3A4 P08684 1/20 0.48
GAA P10253 2/20 0.44
KMT2A Q03164 2/20 0.44
MEN1 O00255 1/20 0.44
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44
NOX1 Q9Y5S8 1/20 0.44
TP53 P04637 1/20 0.44
TYR P14679 1/20 0.44
TSHR P16473 1/20 0.44
LMNA P02545 3/20 0.43
HPGD P15428 2/20 0.43
ALOX15 P16050 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
RECQL P46063 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
PHGDH O43175 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3363637 0.84 ALDH1A1 (0.59) ALDH1A1HSD17B10GAAKMT2AMEN1
SCHEMBL10894670 0.83 HDAC3 (0.57) ALDH1A1HSD17B10GAAKMT2AMEN1
SCHEMBL8587474 0.83 ALDH1A1 (0.62) ALDH1A1GAAKMT2AMEN1NPC1
SCHEMBL9060375 0.83 NPC1 (0.59) ALDH1A1GAAKMT2AMEN1NPC1
SCHEMBL3609938 0.79 KDM4E (0.60) ALDH1A1HSD17B10CYP3A4GAAKMT2A
SCHEMBL11799525 0.79 HDAC3 (0.53) ALDH1A1TAS2R38HSD17B10GAAKMT2A
SCHEMBL3606589 0.78 HSD17B10 (0.44) ALDH1A1TAS2R38HSD17B10CYP3A4KMT2A
SCHEMBL10909195 0.78 ALDH1A1 (0.66) ALDH1A1GAAKMT2ALMNAL3MBTL1
SCHEMBL11370855 0.78 KMT2A (0.55) ALDH1A1CYP3A4GAAKMT2AHPGD
SCHEMBL1285897 0.78 POLB (0.56) ALDH1A1GAAKMT2AMEN1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104093701-B Separation method 旭化成株式会社 2017-05-03 CN disclosed