Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.33 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.33 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27939095 | 0.83 | SLC22A6 (0.54) | DYRK1AGSK3BNFATC1SLC6A4NR3C1 | |
| Quinoline SCHEMBL27875441 | 0.83 | DYRK1A (0.37) | DYRK1AGSK3BNFATC1KDM4EALDH1A1 | |
| SCHEMBL8591739 | 0.77 | CLEC4M (0.42) | SLC22A6KDM4EALDH1A1HPGDCLEC4M | |
| SCHEMBL21806575 | 0.72 | SLC22A6 (0.66) | SLC22A6KDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL24328918 | 0.72 | SMN1; SMN2 (0.57) | DYRK1AGSK3BNFATC1SLC6A4NR3C1 | |
| SCHEMBL19117524 | 0.70 | DYRK1A (0.51) | DYRK1AGSK3BNFATC1SLC6A4NR3C1 | |
| SCHEMBL9936453 | 0.69 | NR4A2 (0.65) | DYRK1AKDM4EALDH1A1HPGDBRPF1 | |
| SCHEMBL24328259 | 0.69 | NR3C1 (0.47) | DYRK1ASLC6A4NR3C1PGRNR3C2 | |
| SCHEMBL2963561 | 0.69 | CLEC4M (0.73) | KDM4EALDH1A1HPGDCLEC4MMEN1 | |
| SCHEMBL1420209 | 0.69 | SMN1; SMN2 (0.52) | NR3C1PGRNR3C2ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106995399-A | A kind of method for preparing Silodosin | 北京天泰恒华医药技术有限公司 | 2017-08-01 | — | — | CN | disclosed |
| CN-106995399-A | A kind of method for preparing Silodosin | 北京天泰恒华医药技术有限公司 | 2017-08-01 | — | — | CN | disclosed |