Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 7/20 | 0.33 |
| ▸ | DRD4 | P21917 | 5/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 6/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28072207 | 1.00 | CHEK1 (0.33) | CHEK1DRD4CHEK2DRD2DRD3 | |
| SCHEMBL28151915 | 1.00 | CHEK1 (0.33) | CHEK1DRD4CHEK2DRD2DRD3 | |
| SCHEMBL28224306 | 0.86 | DRD2 (0.39) | DRD4DRD2DRD3PDK1 | |
| SCHEMBL28224304 | 0.86 | DRD2 (0.39) | DRD4DRD2DRD3PDK1 | |
| SCHEMBL27687247 | 0.84 | PDK1 (0.46) | DRD4DRD2DRD3PDK1HRH3 | |
| SCHEMBL27687249 | 0.84 | PDK1 (0.46) | DRD4DRD2DRD3PDK1HRH3 | |
| SCHEMBL28153145 | 0.84 | PDK1 (0.46) | DRD4DRD2DRD3PDK1HRH3 | |
| SCHEMBL28223636 | 0.83 | DRD4 (0.35) | DRD4DRD2DRD3 | |
| SCHEMBL28224236 | 0.83 | DRD4 (0.35) | DRD4DRD2DRD3 | |
| SCHEMBL28182086 | 0.82 | DRD4 (0.33) | DRD4DRD2DRD3PDK1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108495855-A | Condesned thiazole and pyrimidine derivatives as MNK inhibitor | 生命弧度公司 | 2018-09-04 | — | — | CN | disclosed |
| CN-108175749-A | The solid dispersions of melt extrusion containing cell death inducer | 艾伯维爱尔兰无限公司 | 2018-06-19 | — | — | CN | disclosed |
| CN-103282025-B | Melt-extruded solid dispersions containing apoptosis-inducing agents | 艾伯维爱尔兰无限公司 | 2018-01-02 | — | — | CN | disclosed |
| CN-104876927-B | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | 艾伯维爱尔兰无限公司 | 2017-06-23 | — | — | CN | disclosed |