Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.47 |
| ▸ | PKM | P14618 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 9/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1700614 | 0.87 | LMNA (0.50) | MAPTPKMPOLBSMN1; SMN2HTT | |
| SCHEMBL1700370 | 0.85 | MAPT (0.46) | MAPTPKMPOLBSMN1; SMN2HTT | |
| SCHEMBL27906786 | 0.83 | MAPT (0.48) | MAPTPKMPOLBSMN1; SMN2HTT | |
| SCHEMBL28152133 | 0.82 | KMT2A (0.53) | MAPTPKMPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL28845496 | 0.82 | KMT2A (0.53) | MAPTPKMPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL28199068 | 0.82 | KMT2A (0.53) | MAPTPKMPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL28153060 | 0.81 | ALDH3A1 (0.53) | MAPTPKMPOLBSMN1; SMN2HTT | |
| SCHEMBL1541487 | 0.80 | MAPT (0.64) | MAPTPKMPOLBSMN1; SMN2HTT | |
| SCHEMBL1700213 | 0.79 | MAPT (0.51) | MAPTPKMPOLBSMN1; SMN2HTT | |
| SCHEMBL16038047 | 0.79 | MAPT (0.61) | MAPTPKMPOLBSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108175749-A | The solid dispersions of melt extrusion containing cell death inducer | 艾伯维爱尔兰无限公司 | 2018-06-19 | — | — | CN | disclosed |
| CN-103282025-B | Melt-extruded solid dispersions containing apoptosis-inducing agents | 艾伯维爱尔兰无限公司 | 2018-01-02 | — | — | CN | disclosed |
| CN-104876927-B | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | 艾伯维爱尔兰无限公司 | 2017-06-23 | — | — | CN | disclosed |