Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.68 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | CTSA | P10619 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14825173 | 0.91 | POLB (0.56) | GRM5P2RX7POLBRAB9ANPC1 | |
| SCHEMBL29564594 | 0.85 | POLB (0.49) | GRM5P2RX7POLBRAB9ANPC1 | |
| SCHEMBL23524838 | 0.85 | POLB (0.49) | GRM5P2RX7POLBRAB9ANPC1 | |
| SCHEMBL28438775 | 0.83 | GRM5 (0.64) | GRM5P2RX7POLBRAB9ANPC1 | |
| SCHEMBL28987603 | 0.83 | POLB (0.49) | GRM5P2RX7POLBRAB9ANPC1 | |
| SCHEMBL38657610 | 0.81 | POLB (0.49) | GRM5P2RX7POLBRAB9ANPC1 | |
| SCHEMBL3860067 | 0.81 | GRM5 (1.00) | GRM5P2RX7POLBRAB9ANPC1 | |
| SCHEMBL18157932 | 0.80 | P2RX7 (0.72) | GRM5P2RX7POLBRAB9ANPC1 | |
| SCHEMBL10038817 | 0.79 | NPC1 (0.69) | POLBRAB9ANPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL32060705 | 0.79 | NPC1 (0.69) | POLBRAB9ANPC1SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106928127-B | Substituted piperidine amide derivative, preparation method and pharmaceutical application thereof | 四川海思科制药有限公司 | 2021-07-16 | — | — | CN | disclosed |
| CN-106928127-A | Substituted piperidine class amide derivatives and preparation method thereof and application pharmaceutically | 四川海思科制药有限公司 | 2017-07-07 | — | — | CN | disclosed |