SCHEMBL28153308

SCHEMBL28153308

Cc1ccn(-c2ccc(S(C)(=O)=O)cc2)c1-c1ccc(Cl)cc1C(F)(F)F

nearest known ligand 0.47

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 20/20 0.47
PTGS1 P23219 6/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28152232 0.87 PTGS2 (0.47) PTGS2PTGS1
SCHEMBL27692614 0.83 PTGS2 (0.54) PTGS2PTGS1
SCHEMBL5309162 0.76 PTGS2 (0.61) PTGS2PTGS1
SCHEMBL28766837 0.75 PTGS2 (0.62) PTGS2PTGS1
SCHEMBL5594090 0.70 PTGS2 (0.76) PTGS2PTGS1
SCHEMBL27508363 0.70 PTGS2 (0.47) PTGS2PTGS1
SCHEMBL5316308 0.69 PTGS2 (0.64) PTGS2PTGS1
SCHEMBL5312580 0.68 PTGS2 (0.59) PTGS2PTGS1
SCHEMBL5204407 0.66 PTGS2 (0.53) PTGS2PTGS1
SCHEMBL28480909 0.65 KIF11 (0.40) PTGS2PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102186817-B Atropisomers of (hydroxyalkyl) pyrrole derivatives 埃克塞利希斯股份有限公司 2017-05-17 CN disclosed