SCHEMBL28154196

SCHEMBL28154196

O=C=C1C(=O)CN[C@@H]1C(=O)O

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GRIA2 P42262 1/20 0.32
EGLN1 Q9GZT9 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7875920 0.74 EGLN1 (0.35) GRIA2EGLN1
SCHEMBL27445281 0.72
SCHEMBL23829881 0.69
SCHEMBL4903107 0.61 GRIA2 (0.43) GRIA2
SCHEMBL4903114 0.61 GRIA2 (0.43) GRIA2
SCHEMBL4696355 0.61 AGTR2 (0.32)
Water SCHEMBL27874120 0.60 GRIA2 (0.42) GRIA2
SCHEMBL26096428 0.60
SCHEMBL8630981 0.60 GRIA2 (0.34) GRIA2EGLN1
SCHEMBL29017586 0.59 EGLN1 (0.42) GRIA2EGLN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106029057-B Oral formulations of pyrrolidine derivatives 奥布赛瓦股份公司 2019-09-03 CN disclosed
CN-109928905-A As oxytocins/pitressin V1a receptor antagonist pyrrolidin derivatives 奥布赛瓦股份公司 2019-06-25 CN disclosed
CN-109748836-A As oxytocins/pitressin V1a receptor antagonist pyrrolidin derivatives 奥布赛瓦股份公司 2019-05-14 CN disclosed
CN-107674011-A Pyrrolidin derivatives as oxytocins/pitressin V1a receptor antagonists 奥布赛瓦股份公司 2018-02-09 CN disclosed
CN-106795110-A Crystalline (3Z, 5S) -5- (hydroxymethyl) -1- [ (2 '-methyl-1, 1' -biphenyl-4-yl) carbonyl ] pyrrolidin-3-one O-methyloxime useful in methods of treating disorders associated with OT-R activity 奥布赛瓦股份公司 2017-05-31 CN disclosed