Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | HTR3A | P46098 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.34 |
| ▸ | HTR3B | O95264 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.34 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30889392 | 1.00 | ADRB2 (0.46) | ADRB2TP53LMNAHTTHRH4 | |
| SCHEMBL28161658 | 1.00 | ADRB2 (0.46) | ADRB2TP53LMNAHTTHRH4 | |
| SCHEMBL30315766 | 1.00 | ADRB2 (0.46) | ADRB2TP53LMNAHTTHRH4 | |
| SCHEMBL28161657 | 1.00 | ADRB2 (0.46) | ADRB2TP53LMNAHTTHRH4 | |
| SCHEMBL20009337 | 0.86 | HRH4 (0.38) | TP53LMNAHRH4HTR3AFGFR3 | |
| SCHEMBL1253863 | 0.77 | CYP1A2 (0.53) | HTR3AALDH1A1PDGFRBPDGFRACYP1A2 | |
| SCHEMBL30447104 | 0.77 | CYP1A2 (0.53) | HTR3AALDH1A1PDGFRBPDGFRACYP1A2 | |
| SCHEMBL28467592 | 0.77 | CYP1A2 (0.53) | HTR3AALDH1A1PDGFRBPDGFRACYP1A2 | |
| SCHEMBL20023742 | 0.77 | CYP1A2 (0.53) | HTR3AALDH1A1PDGFRBPDGFRACYP1A2 | |
| SCHEMBL30239388 | 0.77 | CYP1A2 (0.53) | HTR3AALDH1A1PDGFRBPDGFRACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107001328-A | Pyridin-2 (1H) -one quinolinone derivatives as mutant isocitrate dehydrogenase inhibitors | 福马治疗股份有限公司 | 2017-08-01 | — | — | CN | disclosed |