Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Opipramol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 7/20 | 0.80 |
| ▸ | HTR2A known ✓ | P28223 | 5/20 | 0.80 |
| ▸ | SLC6A2 known ✓ | P23975 | 4/20 | 0.80 |
| ▸ | SLC6A4 known ✓ | P31645 | 4/20 | 0.80 |
| ▸ | HRH1 known ✓ | P35367 | 4/20 | 0.80 |
| ▸ | KCNH2 known ✓ | Q12809 | 4/20 | 0.80 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.80 |
| ▸ | MEN1 known ✓ | O00255 | 4/20 | 0.78 |
| ▸ | KMT2A known ✓ | Q03164 | 4/20 | 0.78 |
| ▸ | HTR2B known ✓ | P41595 | 3/20 | 0.48 |
| ▸ | MLNR known ✓ | O43193 | 1/20 | 0.48 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.46 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.46 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 6/20 | 0.80 |
| ▸ | DRD3 | P35462 | 5/20 | 0.80 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.80 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.80 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.80 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Opipramol SCHEMBL17609856 | 1.00 | DRD2 (0.80) | DRD2HTR1AHTR2ADRD3ADRA2A | |
| Opipramol SCHEMBL29414094 | 0.89 | DRD2 (1.00) | DRD2HTR1AHTR2ADRD3ADRA2A | |
| Opipramol SCHEMBL49841 | 0.89 | DRD2 (1.00) | DRD2HTR1AHTR2ADRD3ADRA2A | |
| Opipramol SCHEMBL17609810 | 0.89 | DRD2 (0.82) | DRD2HTR1AHTR2ADRD3ADRA2A | |
| Opipramol SCHEMBL121971 | 0.88 | CYP3A4 (1.00) | DRD2HTR1AHTR2ADRD3ADRA2A | |
| Opipramol SCHEMBL30020862 | 0.88 | CYP3A4 (1.00) | DRD2HTR1AHTR2ADRD3ADRA2A | |
| Opipramol SCHEMBL16416273 | 0.88 | DRD2 (0.97) | DRD2HTR1AHTR2ADRD3ADRA2A | |
| Opipramol SCHEMBL366168 | 0.88 | CYP3A4 (1.00) | DRD2HTR1AHTR2ADRD3ADRA2A | |
| Opipramol SCHEMBL28162242 | 0.88 | DRD2 (0.80) | DRD2HTR1AHTR2ADRD3ADRA2A | |
| Opipramol SCHEMBL21834066 | 0.87 | DRD2 (0.94) | DRD2HTR1AHTR2ADRD3ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106999446-A | Oxapigenin patch | 纽罗德姆有限公司 | 2017-08-01 | — | — | CN | claimed |
| CN-106999446-A | Oxapigenin patch | 纽罗德姆有限公司 | 2017-08-01 | — | — | CN | disclosed |