Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.35 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28172289 | 0.75 | MAPT (0.63) | DAOMAPTRETKDRALPL | |
| SCHEMBL28045657 | 0.74 | MAPT (0.39) | DAOMAPTALDH1A1HCAR2HPGD | |
| SCHEMBL21156922 | 0.71 | HCAR2 (0.52) | DAOMAPTHCAR2 | |
| SCHEMBL1602901 | 0.70 | MAPT (0.54) | MAPTRETKDRALPL | |
| SCHEMBL23189189 | 0.70 | HCAR2 (0.55) | DAOMAPTHCAR2 | |
| SCHEMBL13737667 | 0.69 | ALDH1A1 (0.44) | DAOMAPTALDH1A1HTR2CRET | |
| SCHEMBL28209372 | 0.69 | HPGD (0.47) | DAOALDH1A1HCAR2HPGDTSHR | |
| SCHEMBL24622020 | 0.69 | PTGS1 (0.40) | DAOHCAR2HTR2C | |
| SCHEMBL14313555 | 0.68 | MAPT (0.42) | DAOMAPTALDH1A1HCAR2HPGD | |
| SCHEMBL5103403 | 0.68 | MAPT (0.42) | DAOMAPTALDH1A1HCAR2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108774214-A | Heterocyclic amides as kinase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2018-11-09 | — | — | CN | disclosed |
| CN-105121432-B | Heterocyclic amides as kinase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2018-08-03 | — | — | CN | disclosed |
| CN-106928203-A | Heterocyclic amides as kinase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2017-07-07 | — | — | CN | disclosed |