Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.56 |
| ▸ | PGR | P06401 | 1/20 | 0.56 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.56 |
| ▸ | AR | P10275 | 1/20 | 0.56 |
| ▸ | AHR | P35869 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 3/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28940859 | 0.81 | NR3C1 (0.51) | NR3C1PGRNR3C2ARAHR | |
| SCHEMBL25350212 | 0.75 | AHR (0.39) | NR3C1PGRNR3C2ARAHR | |
| SCHEMBL25593878 | 0.75 | PTPRC (0.39) | NR3C1PGRNR3C2ARAHR | |
| SCHEMBL13085560 | 0.75 | NR3C1 (0.61) | NR3C1PGRNR3C2ARAHR | |
| SCHEMBL19187519 | 0.74 | NR3C1 (0.56) | NR3C1PGRNR3C2ARAHR | |
| SCHEMBL27799452 | 0.74 | CYP2A6 (0.38) | NR3C1PGRNR3C2ARAHR | |
| SCHEMBL28783302 | 0.74 | IKBKB (0.51) | NR3C1PGRNR3C2ARTSHR | |
| SCHEMBL27698981 | 0.73 | KEAP1 (0.56) | NR3C1PGRNR3C2ARAHR | |
| SCHEMBL30026274 | 0.71 | PDPK1 (0.57) | NR3C1PGRNR3C2ARAHR | |
| SCHEMBL6091339 | 0.71 | NR3C1 (0.57) | NR3C1PGRNR3C2ARBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110511209-A | It can be used as the indole carboxamides compound of kinase inhibitor | BRISTOL MYERS SQUIBB CO | 2019-11-29 | — | — | CN | claimed |
| CN-105530932-B | Primary formamide as BTK inhibitor | 艾伯维公司 | 2019-09-27 | — | — | CN | claimed |
| CN-105492444-B | Tricyclic pyridine-carboxamide derivatives as ROCK inhibitors | 百时美施贵宝公司 | 2018-09-07 | — | — | CN | claimed |
| CN-107841532-A | Screen the method for anti-breast cancer transfer compounds and the application of related compound | 清华大学 | 2018-03-27 | — | — | CN | claimed |
| CN-107108583-A | Indole carboxamide compounds useful as kinase inhibitors | 百时美施贵宝公司 | 2017-08-29 | — | — | CN | claimed |
| CN-110511209-A | It can be used as the indole carboxamides compound of kinase inhibitor | BRISTOL MYERS SQUIBB CO | 2019-11-29 | — | — | CN | disclosed |
| CN-105530932-B | Primary formamide as BTK inhibitor | 艾伯维公司 | 2019-09-27 | — | — | CN | disclosed |
| CN-109923107-A | The method for being used to prepare indole carboxamides compound | 百时美施贵宝公司 | 2019-06-21 | — | — | CN | disclosed |
| CN-109923107-A | The method for being used to prepare indole carboxamides compound | 百时美施贵宝公司 | 2019-06-21 | — | — | CN | disclosed |
| CN-108558871-A | Novel tricyclic compound as anticancer agent | 百时美施贵宝公司 | 2018-09-21 | — | — | CN | disclosed |
| CN-105492444-B | Tricyclic pyridine-carboxamide derivatives as ROCK inhibitors | 百时美施贵宝公司 | 2018-09-07 | — | — | CN | disclosed |
| CN-106029663-B | Tricyclic compounds as anticancer agents | 百时美施贵宝公司 | 2018-06-01 | — | — | CN | disclosed |
| CN-104144931-B | Pyrimido [4,5 b] indole derivatives and its application in the amplification of candidate stem cell | 蒙特利尔大学 | 2018-04-10 | — | — | CN | disclosed |
| CN-107841532-A | Screen the method for anti-breast cancer transfer compounds and the application of related compound | 清华大学 | 2018-03-27 | — | — | CN | disclosed |
| CN-107428733-A | CD38 inhibitor and treatment method | 葛兰素史克知识产权第二有限公司 | 2017-12-01 | — | — | CN | disclosed |
| CN-107108583-A | Indole carboxamide compounds useful as kinase inhibitors | 百时美施贵宝公司 | 2017-08-29 | — | — | CN | disclosed |