Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 11/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | LTK | P29376 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | PRKX | P51817 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28164511 | 0.85 | ALDH1A1 (0.42) | KDM4EALDH1A1SMN1; SMN2MAPTHPGD | |
| SCHEMBL9275405 | 0.75 | PARP1 (0.44) | PARP1KDM4EALDH1A1GAAPDPK1 | |
| SCHEMBL30082247 | 0.75 | PARP1 (0.44) | PARP1KDM4EALDH1A1GAAPDPK1 | |
| SCHEMBL23890397 | 0.72 | PARP1 (0.39) | PARP1KDM4EALDH1A1GAAPDPK1 | |
| SCHEMBL23890365 | 0.71 | KDM4E (0.64) | PARP1KDM4EALDH1A1AURKAPARP2 | |
| SCHEMBL28193895 | 0.71 | PARP1 (0.41) | PARP1KDM4EALDH1A1GAAPDPK1 | |
| SCHEMBL22414206 | 0.67 | FABP4 (0.43) | KDM4EALDH1A1SMN1; SMN2MAPTHPGD | |
| SCHEMBL1290332 | 0.66 | PARP1 (0.47) | PARP1KDM4EAURKA | |
| SCHEMBL22414132 | 0.65 | KDM4E (0.43) | PARP1KDM4EALDH1A1PARP2PARP3 | |
| SCHEMBL27722750 | 0.65 | PARP1 (0.49) | PARP1KDM4EALDH1A1GAAPDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110511209-A | It can be used as the indole carboxamides compound of kinase inhibitor | BRISTOL MYERS SQUIBB CO | 2019-11-29 | — | — | CN | disclosed |
| CN-107108583-A | Indole carboxamide compounds useful as kinase inhibitors | 百时美施贵宝公司 | 2017-08-29 | — | — | CN | disclosed |