Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.88 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.56 |
| ▸ | TET3 | O43151 | 2/20 | 0.56 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.56 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.50 |
| ▸ | KDM4A | O75164 | 2/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.48 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.48 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL21145210 | 0.97 | SMN1; SMN2 (0.83) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL21145212 | 0.97 | SMN1; SMN2 (0.83) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL31673494 | 0.94 | — | — | |
| Malic Acid SCHEMBL98496 | 0.94 | — | — | |
| Malic Acid SCHEMBL28355917 | 0.94 | SMN1; SMN2 (1.00) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL31673489 | 0.94 | — | — | |
| Malic Acid SCHEMBL89131 | 0.94 | SMN1; SMN2 (1.00) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL14125844 | 0.94 | SMN1; SMN2 (1.00) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL256122 | 0.94 | — | — | |
| Malic Acid SCHEMBL856 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115572355-A | Water-reducing slump-retaining water reducer and preparation method thereof | 中铁十一局集团有限公司 | 2023-01-06 | — | — | CN | disclosed |
| CN-107159070-A | Self-repairing microcapsule and preparation method thereof, coating, coating and epoxy resin composite material | 中国人民解放军装甲兵工程学院 | 2017-09-15 | — | — | CN | disclosed |
| CN-107138105-A | Synthetic method, self-healing coatings and the coating of self-repairing microcapsule | 中国人民解放军装甲兵工程学院 | 2017-09-08 | — | — | CN | disclosed |
| CN-107072960-A | Method for preparing multiple capsules | 国际香料和香精公司 | 2017-08-18 | — | — | CN | disclosed |