Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 2/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.34 |
| ▸ | HTR2C | P28335 | 3/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.32 |
| ▸ | TEK | Q02763 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
| ▸ | MAT2A | P31153 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28279023 | 0.83 | KLKB1 (0.53) | KLKB1MAOBMCHR1HTR2C | |
| SCHEMBL28279003 | 0.82 | KLKB1 (0.53) | KLKB1MAOBMCHR1HTR2C | |
| SCHEMBL17785263 | 0.73 | KLKB1 (0.63) | KLKB1 | |
| SCHEMBL31339410 | 0.73 | KLKB1 (0.63) | KLKB1 | |
| SCHEMBL17785314 | 0.72 | KLKB1 (0.65) | KLKB1 | |
| SCHEMBL28169400 | 0.68 | PDGFRB (0.50) | PDGFRBPDGFRAMAOBMCHR1HTR2C | |
| SCHEMBL12507578 | 0.68 | PDGFRB (0.50) | PDGFRBPDGFRAMAOBHRH4DAO | |
| SCHEMBL17785303 | 0.67 | KLKB1 (0.58) | KLKB1 | |
| SCHEMBL16880666 | 0.67 | PDGFRB (0.51) | KLKB1PDGFRBPDGFRAMAOBMCHR1 | |
| SCHEMBL40698 | 0.66 | PDGFRB (0.47) | PDGFRBPDGFRAMAOBPDE10AHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107108576-A | N- ((hetero) arylmethyl) -heteroaryl-carboxamide compounds as plasma kallikrein inhibitors | 卡尔维斯塔制药有限公司 | 2017-08-29 | — | — | CN | disclosed |