SCHEMBL28174271

SCHEMBL28174271

O=Nc1c[nH]c(=O)c(C(F)(F)F)c1

nearest known ligand 0.33

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 2/20 0.33
GRIA1 P42261 1/20 0.33
GRIA2 P42262 1/20 0.33
GRIA3 P42263 1/20 0.33
GRIA4 P48058 1/20 0.33
KMT2A Q03164 1/20 0.33
ALDH1A1 P00352 2/20 0.31
GAA P10253 2/20 0.31
KDM4E B2RXH2 1/20 0.31
TP53 P04637 1/20 0.31
GLA P06280 1/20 0.31
HPGD P15428 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25044537 0.72 DAO (0.50) KMT2AALDH1A1GAAKDM4ETP53
SCHEMBL1857404 0.72 ERCC1 (0.50) PARP1GRIA1GRIA2GRIA3GRIA4
SCHEMBL2995837 0.72 PKM (0.54) PARP1GRIA1GRIA2GRIA3GRIA4
SCHEMBL14407007 0.72 DAO (0.50) PARP1GRIA1GRIA2GRIA3GRIA4
SCHEMBL12496065 0.69 GRIN2D (0.38) PARP1GRIA1GRIA2GRIA3GRIA4
SCHEMBL15829213 0.69 ALDH1A1 (0.39) PARP1KMT2AALDH1A1GAAKDM4E
SCHEMBL23048401 0.69 GRIA1 (0.39) PARP1GRIA1GRIA2GRIA3GRIA4
SCHEMBL15358113 0.68 ALDH1A1 (0.44) KMT2AALDH1A1GAAKDM4ETP53
SCHEMBL15807125 0.68 HTR2A (0.39) ALDH1A1GAAKDM4ETP53GLA
SCHEMBL14332902 0.68 NOTUM (0.47) KMT2AALDH1A1KDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107074846-A Harmful organism active heterocycles derivative is killed with sulfur-bearing substituent 先正达参股股份有限公司 2017-08-18 CN disclosed