Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Di(Hydroxyethyl)Ether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lactic Acid SCHEMBL6064556 | 0.89 | MEN1 (0.44) | TP53TSHRMAPK1MEN1KMT2A | |
| Di(Hydroxyethyl)Ether SCHEMBL9561716 | 0.87 | TSHR (0.53) | TP53TSHRMAPK1MEN1KMT2A | |
| Di(Hydroxyethyl)Ether SCHEMBL8756145 | 0.86 | TP53 (0.41) | TP53TSHRMAPK1MEN1KMT2A | |
| Triethylene Glycol SCHEMBL2213080 | 0.85 | MEN1 (0.55) | TP53TSHRMAPK1MEN1KMT2A | |
| Tetraethylene Glycol SCHEMBL7637829 | 0.85 | MEN1 (0.55) | TP53TSHRMAPK1MEN1KMT2A | |
| Lactic Acid SCHEMBL5189394 | 0.84 | HTT (0.66) | TSHRMEN1KMT2ATHRBHTT | |
| Lactic Acid SCHEMBL2490435 | 0.83 | TP53 (0.52) | TP53MEN1KMT2AALDH1A1OR51E2 | |
| Di(Hydroxyethyl)Ether SCHEMBL1171068 | 0.83 | TSHR (0.48) | TP53TSHRMAPK1MEN1KMT2A | |
| Di(Hydroxyethyl)Ether SCHEMBL29239546 | 0.83 | TSHR (0.48) | TP53TSHRMAPK1MEN1KMT2A | |
| Di(Hydroxyethyl)Ether SCHEMBL29124601 | 0.83 | TSHR (0.48) | TP53TSHRMAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106572855-B | For reinforcing weaving and the fibrous material of staple line | 伊西康内外科有限责任公司 | 2019-10-25 | — | — | CN | disclosed |
| CN-107155296-A | Device for sealing staples in tissue | 伊西康内外科有限责任公司 | 2017-09-12 | — | — | CN | disclosed |