Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Di(Hydroxyethyl)Ether SCHEMBL28174751 | 0.89 | TP53 (0.55) | MEN1KMT2ATP53TSHRMAPK1 | |
| Alanine SCHEMBL28494565 | 0.88 | MEN1 (0.44) | MEN1KMT2ATSHRMAPK1THRB | |
| Lactic Acid SCHEMBL2490435 | 0.87 | TP53 (0.52) | MEN1KMT2ATP53ALDH1A1OR51E2 | |
| Lactic Acid SCHEMBL28158391 | 0.85 | TP53 (0.61) | MEN1KMT2ATP53TSHRALDH1A1 | |
| Di(Hydroxyethyl)Ether SCHEMBL29026583 | 0.83 | MEN1 (0.52) | MEN1KMT2ATSHRMAPK1THRB | |
| SCHEMBL28870350 | 0.83 | MEN1 (0.52) | MEN1KMT2ATSHRMAPK1THRB | |
| Acetic Acid SCHEMBL2513783 | 0.83 | MEN1 (0.52) | MEN1KMT2ATSHRMAPK1THRB | |
| Acetic Acid SCHEMBL2515140 | 0.83 | MEN1 (0.52) | MEN1KMT2ATSHRMAPK1THRB | |
| Hydrogen Peroxide SCHEMBL28866224 | 0.82 | MEN1 (0.65) | MEN1KMT2ATSHRMAPK1THRB | |
| Propylene Glycol SCHEMBL28304554 | 0.81 | MEN1 (0.50) | MEN1KMT2ATSHRMAPK1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060148947-A1 | Plasticizer for resin, and resin composition | ARAKAWA CHEMICAL INDUSTRIES, LTD. (JP) | 2006-07-06 | — | — | US | disclosed |
| EP-1589075-A1 | PLASTICIZER FOR RESIN AND RESIN COMPOSITION | Arakawa Chemical Industries, Ltd. (JP) | 2005-10-26 | — | — | EP | disclosed |