Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL8948447 | 0.92 | FFAR3 (0.39) | TSHRFFAR3USP2TP53MGAM | |
| SCHEMBL48647 | 0.87 | — | — | |
| SCHEMBL20591070 | 0.79 | MME (0.42) | TSHRTP53CA2MAPK1CHRM1 | |
| SCHEMBL27566177 | 0.76 | TGFBR1 (0.47) | USP2 | |
| SCHEMBL29072198 | 0.74 | LMNA (0.42) | TSHRCHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL20239040 | 0.74 | — | — | |
| SCHEMBL851277 | 0.74 | — | — | |
| SCHEMBL3749851 | 0.74 | SLC22A6 (0.37) | FFAR3TDP1ALDH1A1GPR84 | |
| Bicarbonate SCHEMBL5083789 | 0.74 | — | — | |
| SCHEMBL5698964 | 0.73 | LMNA (0.38) | TSHRCA2ADRA1ATDP1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107266698-B | Hydroxypropylation ammonium carbonate salts compound mixture, preparation method and purposes | 唐宇煊 | 2018-02-13 | — | — | CN | claimed |
| CN-107266698-A | Hydroxypropylation ammonium carbonate salts compound mixture, preparation method and purposes | 补天新材料技术有限公司 | 2017-10-20 | — | — | CN | claimed |
| CN-109422913-A | Foaming agent comprising polyamines salt and propyl alcohol amine salt and the purposes for polyurethane refrigerator ice cabinet foam-body material | 补天新材料技术有限公司 | 2019-03-05 | — | — | CN | disclosed |
| CN-109422894-A | Foaming agent comprising tertiary ammonium salt and propyl alcohol amine salt and the purposes for polyurethane refrigerator ice cabinet foam-body material | 山东理工大学 | 2019-03-05 | — | — | CN | disclosed |
| CN-109422909-A | Orthoformic acid alcohol amine salt and carbonate polyol amine salt alkalinity foaming agent and the purposes for being used to prepare polyurethane coating foam-body material | 补天新材料技术有限公司 | 2019-03-05 | — | — | CN | disclosed |
| CN-109422895-A | Tertiary amine and hydramine alkalinity foaming agent and the purposes for being used to prepare polyurethane coating foam-body material | 山东理工大学 | 2019-03-05 | — | — | CN | disclosed |
| CN-109422896-A | Foaming agent comprising primary amine salt and propyl alcohol amine salt and the purposes for polyurethane refrigerator ice cabinet foam-body material | 山东理工大学 | 2019-03-05 | — | — | CN | disclosed |
| CN-109422917-A | Secondary amine and hydramine alkalinity foaming agent and the purposes for being used to prepare polyurethane coating foam-body material | 山东理工大学 | 2019-03-05 | — | — | CN | disclosed |
| CN-109422903-A | Foaming agent comprising secondary amine salt and propyl alcohol amine salt and the purposes for polyurethane refrigerator ice cabinet foam-body material | 山东理工大学 | 2019-03-05 | — | — | CN | disclosed |
| CN-109422911-A | Foaming agent comprising orthoformic acid alcohol amine salt and propyl alcohol amine salt and the purposes for polyurethane refrigerator ice cabinet foam-body material | 补天新材料技术有限公司 | 2019-03-05 | — | — | CN | disclosed |
| CN-109422912-A | Alkaline polyamines hydramine foaming agent and the purposes for being used to prepare polyurethane coating foam-body material | 补天新材料技术有限公司 | 2019-03-05 | — | — | CN | disclosed |
| CN-109422901-A | Alkaline hydramine foaming agent and the purposes for being used to prepare polyurethane coating foam-body material | 山东理工大学 | 2019-03-05 | — | — | CN | disclosed |
| CN-107266698-B | Hydroxypropylation ammonium carbonate salts compound mixture, preparation method and purposes | 唐宇煊 | 2018-02-13 | — | — | CN | disclosed |
| CN-107266698-B | Hydroxypropylation ammonium carbonate salts compound mixture, preparation method and purposes | 唐宇煊 | 2018-02-13 | — | — | CN | disclosed |
| CN-107266698-A | Hydroxypropylation ammonium carbonate salts compound mixture, preparation method and purposes | 补天新材料技术有限公司 | 2017-10-20 | — | — | CN | disclosed |
| CN-107266698-A | Hydroxypropylation ammonium carbonate salts compound mixture, preparation method and purposes | 补天新材料技术有限公司 | 2017-10-20 | — | — | CN | disclosed |