Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Benzamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | PARP1 | P09874 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | ALPI | P09923 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | XIAP | P98170 | 1/20 | 0.48 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.48 |
| ▸ | KIF11 | P52732 | 1/20 | 0.48 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzamide SCHEMBL28175462 | 1.00 | TSHR (0.59) | TSHRPOLBCYP3A4PARP1MAPT | |
| Aspartic Acid SCHEMBL2772548 | 0.87 | TSHR (0.54) | TSHRALPIPKMPTGS1XIAP | |
| Aspartic Acid SCHEMBL2772547 | 0.87 | TSHR (0.54) | TSHRALPIPKMPTGS1XIAP | |
| Benzamide SCHEMBL6443169 | 0.83 | TSHR (0.61) | TSHRPOLBCYP3A4PARP1MAPT | |
| Biphenyl SCHEMBL7779541 | 0.82 | SLC1A3 (0.62) | ALPIPKMPTGS1XIAPSLC7A5 | |
| D-Glutamate SCHEMBL28817934 | 0.82 | GRM8 (0.62) | TSHRPOLBCYP3A4PARP1MAPT | |
| Glutamic Acid SCHEMBL28817932 | 0.82 | GRM8 (0.62) | TSHRPOLBCYP3A4PARP1MAPT | |
| Leucine SCHEMBL9068238 | 0.82 | SLC7A5 (0.62) | TSHRPOLBCYP3A4PARP1MAPT | |
| Benzamide SCHEMBL4390826 | 0.81 | PTGS1 (0.59) | TSHRPOLBCYP3A4PARP1MAPT | |
| Benzamide SCHEMBL27802023 | 0.81 | TSHR (0.59) | TSHRPOLBCYP3A4PARP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107074768-A | The Pyridione derivatives of (RET) kinase inhibitor are reset as transfection | 葛兰素史克知识产权发展有限公司 | 2017-08-18 | — | — | CN | disclosed |