Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | PARP1 | P09874 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.59 |
| ▸ | ALPI | P09923 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | XIAP | P98170 | 1/20 | 0.48 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.48 |
| ▸ | KIF11 | P52732 | 4/20 | 0.48 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzophenone SCHEMBL29200984 | 0.87 | PTGS1 (0.61) | PTGS1TDP1L3MBTL1SLC7A11ALPI | |
| Benzoic Acid SCHEMBL28091952 | 0.87 | PTGS1 (0.61) | PTGS1TSHRSLC7A11ALPIPKM | |
| Benzil SCHEMBL5579330 | 0.87 | PTGS1 (0.61) | PTGS1SLC7A11ALPIPKMXIAP | |
| Benzil SCHEMBL5579332 | 0.87 | PTGS1 (0.61) | PTGS1SLC7A11ALPIPKMXIAP | |
| Benzoic Acid SCHEMBL28976988 | 0.84 | PTGS1 (0.57) | PTGS1TSHRSLC7A11ALPIPKM | |
| Benzamide SCHEMBL6443169 | 0.83 | TSHR (0.61) | PTGS1POLBCYP3A4PARP1MAPT | |
| Niacinamide SCHEMBL5946479 | 0.82 | F7 (0.65) | PTGS1CYP2C19TDP1SLC7A11 | |
| Biphenyl SCHEMBL27974455 | 0.82 | PTGS1 (0.67) | PTGS1SLC7A11ALPIPKMXIAP | |
| Cysteine SCHEMBL28009382 | 0.82 | PTGS1 (0.89) | PTGS1BLMPMP22SLC7A11ALPI | |
| Benzamide SCHEMBL28175463 | 0.81 | TSHR (0.59) | PTGS1POLBCYP3A4PARP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1435964-B1 | NOVEL PRODRUGS OF N-H BOND-CONTAINING COMPOUNDS AND METHODS OF MAKING THEREOF | UNIV KANSAS (US) | 2009-12-09 | — | — | EP | disclosed |
| EP-1435964-A4 | NOVEL PRODRUGS OF N-H BOND-CONTAINING COMPOUNDS AND METHODS OF MAKING THEREOF | UNIV KANSAS (US) | 2005-01-19 | — | — | EP | disclosed |
| EP-1435964-A2 | NOVEL PRODRUGS OF N-H BOND-CONTAINING COMPOUNDS AND METHODS OF MAKING THEREOF | The University of Kansas (US) | 2004-07-14 | — | — | EP | disclosed |
| US-20030119814-A1 | Novel prodrugs of N-H bond-containing compounds and methods of making thereof | THE UNIVERSITY OF KANSAS | 2003-06-26 | — | — | US | disclosed |
| WO-2003032908-A2 | NOVEL PRODRUGS OF N-H BOND-CONTAINING COMPOUNDS AND METHODS OF MAKING THEREOF | UNIVERSITY OF KANSAS (US) | 2003-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030119814-A1 | Novel prodrugs of N-H bond-containing compounds and methods of making thereof | CTH, CBS, GSTP1 | PTGS1 108/4885POLB 4177/4885CYP3A4 136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.