Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 9/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2791612 | 1.00 | PROKR1 (0.39) | PROKR1CNR2FPR2ITGB3ITGA2B | |
| SCHEMBL7891183 | 0.91 | PADI4 (0.40) | PROKR1CNR2PADI4 | |
| SCHEMBL2789237 | 0.89 | CNR2 (0.37) | CNR2FPR2ITGB3ITGA2BALDH1A1 | |
| SCHEMBL2789818 | 0.89 | CNR2 (0.35) | PROKR1CNR2FPR2ITGB3ITGA2B | |
| SCHEMBL2791987 | 0.88 | PROKR1 (0.35) | PROKR1FPR2ITGB3ITGA2BALDH1A1 | |
| SCHEMBL2792434 | 0.88 | PROKR1 (0.40) | PROKR1CNR2ALDH1A1MAPTCYP1A2 | |
| SCHEMBL2790813 | 0.88 | PROKR1 (0.36) | PROKR1CNR2ITGB3ITGA2BALDH1A1 | |
| SCHEMBL2791389 | 0.88 | CNR2 (0.40) | PROKR1CNR2ALDH1A1PADI4HPGD | |
| SCHEMBL2790320 | 0.87 | KDM4E (0.42) | PROKR1FPR2ITGB3ITGA2BALDH1A1 | |
| SCHEMBL2791193 | 0.87 | PROKR1 (0.41) | PROKR1FPR2ITGB3ITGA2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |