Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 7/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 6/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | EP300 | Q09472 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2817635 | 0.88 | PROKR1 (0.39) | PROKR1ITGB3ITGA2BFPR2KMT2A | |
| SCHEMBL2791612 | 0.88 | PROKR1 (0.39) | PROKR1ITGB3ITGA2BFPR2KMT2A | |
| SCHEMBL7901541 | 0.86 | PADI4 (0.36) | PROKR1ITGB3ITGA2BP2RX3 | |
| SCHEMBL7891183 | 0.82 | PADI4 (0.40) | PROKR1 | |
| SCHEMBL2790320 | 0.82 | KDM4E (0.42) | PROKR1ITGB3ITGA2BFPR2MEN1 | |
| SCHEMBL7900021 | 0.81 | PROKR1 (0.34) | PROKR1P2RX3 | |
| SCHEMBL2790813 | 0.78 | PROKR1 (0.36) | PROKR1ITGB3ITGA2BKMT2AALDH1A1 | |
| SCHEMBL2789237 | 0.78 | CNR2 (0.37) | ITGB3ITGA2BFPR2KMT2AALDH1A1 | |
| SCHEMBL7900016 | 0.78 | PROKR1 (0.42) | PROKR1MEN1KMT2A | |
| SCHEMBL7900939 | 0.77 | TP53 (0.37) | PROKR1ITGB3ITGA2BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |