Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Purine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | CPB1 | P15086 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | TOP2A | P11388 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Purine SCHEMBL8066127 | 0.89 | SMN1; SMN2 (0.37) | SMN1; SMN2NTRK1TP53KDM4EALDH1A1 | |
| Purine SCHEMBL21998271 | 0.89 | SMN1; SMN2 (0.37) | SMN1; SMN2NTRK1TP53KDM4EALDH1A1 | |
| Purine SCHEMBL28153340 | 0.89 | KDM4E (0.39) | SMN1; SMN2NTRK1TP53KDM4EALDH1A1 | |
| Purine SCHEMBL28724547 | 0.85 | SMN1; SMN2 (0.38) | SMN1; SMN2NTRK1TP53KDM4EALDH1A1 | |
| Purine SCHEMBL5788025 | 0.85 | SLC7A5 (0.42) | SMN1; SMN2NTRK1TP53KDM4EALDH1A1 | |
| Purine SCHEMBL29465224 | 0.85 | ALDH1A1 (0.39) | SMN1; SMN2NTRK1KDM4EALDH1A1RXFP1 | |
| Purine SCHEMBL28164598 | 0.85 | ALDH1A1 (0.44) | TP53KDM4EALDH1A1RXFP1CYP1A2 | |
| Purine SCHEMBL28299820 | 0.83 | SMN1; SMN2 (0.39) | SMN1; SMN2NTRK1TP53KDM4EALDH1A1 | |
| Purine SCHEMBL27575443 | 0.83 | ALDH1A1 (0.42) | TP53KDM4EALDH1A1RXFP1CYP1A2 | |
| Purine SCHEMBL9934578 | 0.82 | ALDH1A1 (0.41) | SMN1; SMN2NTRK1TP53KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4585923-A1 | METHOD AND KIT FOR DIAGNOSING MIDD | East China University of Science and Technology (CN) | 2025-07-16 | — | — | EP | disclosed |
| CN-110684685-B | Lactobacillus fermentum 9-4 and application thereof | 广西大学 | 2021-03-30 | — | — | CN | disclosed |
| CN-110684685-A | Lactobacillus fermentum 9-4 and application thereof | 广西大学 | 2020-01-14 | — | — | CN | disclosed |
| CN-107208029-A | Lactic acid bacteria of ability and application thereof is absorbed with purine | 株式会社明治 | 2017-09-26 | — | — | CN | disclosed |