Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8252 | 0.88 | CYP3A4 (0.52) | MAPTCA1CA2ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL27904367 | 0.86 | MAPT (0.56) | MAPTCA1CA2ALDH1A1HPGD | |
| Bromide SCHEMBL28406943 | 0.86 | CYP3A4 (0.50) | MAPTCA1CA2ALDH1A1HPGD | |
| Naphthalene SCHEMBL9463547 | 0.82 | CYP3A4 (0.46) | MAPTCA1CA2KMT2AIDO1 | |
| SCHEMBL28377529 | 0.80 | CYP3A4 (0.45) | MAPTCA1CA2ALDH1A1HPGD | |
| SCHEMBL2542923 | 0.78 | CYP1A2 (0.47) | MAPTL3MBTL1CA1CA2HPGD | |
| Benzaldehyde SCHEMBL8037478 | 0.78 | ALDH1A1 (0.50) | MAPTCA1CA2ALDH1A1KMT2A | |
| Trifluoromethanesulfonic Acid SCHEMBL3921319 | 0.78 | HTT (0.43) | MAPTCA1CA2ALDH1A1SMN1; SMN2 | |
| Carbamic Acid SCHEMBL15635796 | 0.77 | HDAC8 (0.60) | MAPTCA1CA2CYP1A2CYP2D6 | |
| Pyrimidine SCHEMBL28155909 | 0.77 | CYP3A4 (0.42) | MAPTALDH1A1HPGDCYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109966240-A | The subcutaneously composition and method of fatty local delivery prostaglandin | 托普凯恩制药公司 | 2019-07-05 | — | — | CN | disclosed |
| CN-109265400-A | Arginine methyltransferase inhibitor and application thereof | EPIZYME股份有限公司 | 2019-01-25 | — | — | CN | disclosed |
| CN-104718202-B | The method for being used to prepare (S) -3- (4- ((4- (morpholinyl methyl) benzyl) oxygroup) -1- oxoisoindolines -2- base) piperidine-2,6-diones and its pharmaceutically acceptable form | 细胞基因公司 | 2018-11-20 | — | — | CN | disclosed |
| CN-105209015-B | Compositions and methods for local delivery of prostaglandins to subcutaneous fat | 托普凯恩制药公司 | 2018-11-20 | — | — | CN | disclosed |
| CN-105339351-B | Arginine methyltransferase inhibitors and uses thereof | EPIZYME股份有限公司 | 2018-11-06 | — | — | CN | disclosed |
| CN-105228997-B | Carm1 inhibitors and uses thereof | EPIZYME股份有限公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-105452226-B | Tetrahydro-and dihydro-isoquinoline PRMT5 inhibitors and uses thereof | EPIZYME股份有限公司 | 2017-09-12 | — | — | CN | disclosed |