Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 15/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 15/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 13/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | RBP4 | P02753 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9493435 | 0.81 | CYP11B2 (0.43) | MAPK1CYP11B2 | |
| SCHEMBL9493247 | 0.81 | CYP11B2 (0.43) | MAPK1CYP11B2 | |
| SCHEMBL2817700 | 0.81 | CYP11B2 (0.43) | MAPK1CYP11B2 | |
| SCHEMBL2817669 | 0.80 | MAPK1 (0.40) | MAPK1CYP11B2CYP11B1IDO1 | |
| SCHEMBL2819171 | 0.80 | MAPK1 (0.40) | SLC6A2SLC6A4SLC6A3MAPK1CYP11B2 | |
| SCHEMBL10387698 | 0.79 | MAPK1 (0.40) | MAPK1CYP11B2RBP4CYP11B1IDO1 | |
| SCHEMBL3190003 | 0.75 | MAPK1 (0.47) | SLC6A4SLC6A3MAPK1CYP11B2CYP11B1 | |
| SCHEMBL2819823 | 0.74 | MAPK1 (0.42) | MAPK1CYP11B2CYP11B1IDO1 | |
| SCHEMBL2817741 | 0.74 | CYP11B2 (0.43) | MAPK1CYP11B2CYP11B1IDO1TDO2 | |
| SCHEMBL2819821 | 0.74 | MAPK1 (0.42) | MAPK1CYP11B2CYP11B1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8436035-B2 | Organic compounds | NOVARTIS AG (CH) | 2013-05-07 | — | — | US | disclosed |
| US-8436035-B2 | Organic compounds | NOVARTIS AG (CH) | 2013-05-07 | — | — | US | disclosed |
| EP-2213668-A2 | Imidazoles as aldosterone synthase inhibitors | Novartis AG (CH) | 2010-08-04 | — | — | EP | disclosed |
| US-20100048562-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-02-25 | — | — | US | disclosed |
| US-20100048562-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-02-25 | — | — | US | disclosed |
| US-20100048562-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-02-25 | — | — | US | disclosed |
| EP-2094807-A1 | REACTIVE ADHESIVE | Henkel AG & Co. KGaA (DE) | 2009-09-02 | — | — | EP | disclosed |
| EP-2094680-A2 | IMIDAZOLES AS ALDOSTERONE SYNTHASE INHIBITORS | Novartis AG (CH) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008076336-A2 | IMIDAZOLES AS ALDOSTERONE SYNTHASE INHIBITORS | NOVARTIS AG (CH) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008076336-A2 | IMIDAZOLES AS ALDOSTERONE SYNTHASE INHIBITORS | NOVARTIS AG (CH) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008061828-A1 | REACTIVE ADHESIVE | HENKEL AG & CO. KGAA (DE) | 2008-05-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048562-A1 | ORGANIC COMPOUNDS | CYP11B1, HSD11B1, CYP17A1 | SLC6A2 2586/4885SLC6A4 3167/4885SLC6A3 3879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.