Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.40 |
| ▸ | OTC | P00480 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | GSTK1 | Q9Y2Q3 | 1/20 | 0.39 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.38 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.36 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.36 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | NPY4R | P50391 | 6/20 | 0.35 |
| ▸ | NPY1R | P25929 | 5/20 | 0.35 |
| ▸ | NPY2R | P49146 | 4/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.35 |
| ▸ | RRM1 | P23921 | 1/20 | 0.35 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2117673 | 0.92 | DPP7 (0.46) | DPP7OTCPTGS1GSTK1DDAH1 | |
| SCHEMBL29476574 | 0.92 | DPP7 (0.46) | DPP7OTCPTGS1GSTK1DDAH1 | |
| SCHEMBL2117664 | 0.92 | DPP7 (0.46) | DPP7OTCPTGS1GSTK1DDAH1 | |
| Arginine SCHEMBL150229 | 0.89 | OTC (0.49) | OTCDDAH1NOS3NOS1NOS2 | |
| Arginine SCHEMBL248897 | 0.89 | OTC (0.49) | OTCDDAH1NOS3NOS1NOS2 | |
| Arginine SCHEMBL27692295 | 0.89 | OTC (0.49) | OTCDDAH1NOS3NOS1NOS2 | |
| Arginine SCHEMBL150228 | 0.89 | OTC (0.49) | OTCDDAH1NOS3NOS1NOS2 | |
| Arginine SCHEMBL27530824 | 0.89 | OTC (0.49) | OTCDDAH1NOS3NOS1NOS2 | |
| SCHEMBL30259956 | 0.87 | DPP7 (0.49) | DPP7OTCPTGS1GSTK1NOD1 | |
| Arginine SCHEMBL8047291 | 0.87 | OTC (0.48) | OTCDDAH1NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107207564-A | Target XTEN conjugate compositions and preparation method thereof | 阿穆尼克斯运营公司 | 2017-09-26 | — | — | CN | disclosed |