Methylene Chloride

Methylene Chloride

SCHEMBL28181772

CC(=O)c1ccccc1C(=O)O.ClCCl

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.61
ALOX15 P16050 1/20 0.61
CA12 O43570 3/20 0.48
CA1 P00915 3/20 0.48
CA2 P00918 3/20 0.48
CA4 P22748 3/20 0.48
CA7 P43166 3/20 0.48
CA9 Q16790 3/20 0.48
AKR1C3 P42330 3/20 0.48
KDM4E B2RXH2 2/20 0.47
HMGB1 P09429 2/20 0.47
HPGD P15428 2/20 0.47
NAPRT Q6XQN6 2/20 0.47
TDP1 Q9NUW8 2/20 0.47
ESR1 P03372 1/20 0.47
ITGB3 P05106 1/20 0.47
ITGA2B P08514 1/20 0.47
TSHR P16473 1/20 0.47
GGT1 P19440 1/20 0.47
PTGS1 P23219 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzene SCHEMBL11756425 0.91 ALDH1A1 (0.74) ALDH1A1ALOX15CA12CA1CA2
SCHEMBL286653 0.91 ALDH1A1 (0.74) ALDH1A1ALOX15CA12CA1CA2
SCHEMBL3966730 0.89 ALDH1A1 (0.70) ALDH1A1ALOX15CA12CA1CA2
Hydrochloric Acid SCHEMBL9464739 0.89 ALDH1A1 (0.70) ALDH1A1ALOX15CA12CA1CA2
Chlorobenzene SCHEMBL27863368 0.85 ALDH1A1 (0.58) ALDH1A1ALOX15CA12CA1CA2
SCHEMBL28427057 0.84 ALDH1A1 (0.64) ALDH1A1ALOX15CA12CA1CA2
Phthalic Acid SCHEMBL10600451 0.84 ALDH1A1 (0.70) ALDH1A1ALOX15CA12CA1CA2
Benzoic Acid SCHEMBL27618278 0.83 ALDH1A1 (0.61) ALDH1A1ALOX15CA12CA1CA2
Phthalic Acid SCHEMBL7897915 0.81 ALDH1A1 (0.82) ALDH1A1ALOX15CA12CA1CA2
Phthalic Acid SCHEMBL2777 0.81 ALDH1A1 (0.82) ALDH1A1ALOX15CA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105055375-B Adriamycin and resveratrol with the effect of anti-multidrug resistance deliver nanoscale medicine delivery system altogether 中国人民解放军第四军医大学 2017-11-14 CN claimed
CN-105055375-B Adriamycin and resveratrol with the effect of anti-multidrug resistance deliver nanoscale medicine delivery system altogether 中国人民解放军第四军医大学 2017-11-14 CN disclosed