Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28184049 | 0.86 | DDB1 (0.38) | DDB1CRBNNPC1LMNARAB9A | |
| SCHEMBL28183316 | 0.80 | KDM4E (0.33) | SMN1; SMN2TLR7 | |
| SCHEMBL28184098 | 0.78 | MAPK1 (0.39) | NPC1RAB9ASIRT1TLR7KMT2A | |
| SCHEMBL28183270 | 0.77 | DDB1 (0.39) | DDB1CRBNLMNASMN1; SMN2SIRT1 | |
| SCHEMBL9798165 | 0.74 | HPRT1 (0.47) | DDB1CRBNLMNASIRT1TLR7 | |
| SCHEMBL28183208 | 0.69 | ABCB1 (0.38) | NPC1LMNARAB9ASMN1; SMN2TLR7 | |
| SCHEMBL18207577 | 0.68 | TLR7 (0.67) | TLR7 | |
| SCHEMBL28184056 | 0.67 | POLB (0.36) | LMNARAB9ATLR7SLC2A1ALDH1A1 | |
| SCHEMBL28183273 | 0.66 | SMN1; SMN2 (0.33) | LMNASMN1; SMN2KMT2ACYP1A2CYP2C19 | |
| SCHEMBL28184079 | 0.65 | ALDH1A1 (0.35) | TLR7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107580596-A | For treating and preventing the new sulphur imido acyl group purinone compound and derivative of virus infection | 豪夫迈·罗氏有限公司 | 2018-01-12 | — | — | CN | disclosed |