Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | BRS3 | P32247 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | STAT1 | P42224 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2771948 | 0.91 | KDM4E (0.39) | BRS3MMP12KDM4ENPC1ALDH1A1 | |
| SCHEMBL2814812 | 0.84 | FAAH (0.43) | — | |
| SCHEMBL2814345 | 0.81 | FAAH (0.45) | MMP12 | |
| SCHEMBL2860899 | 0.81 | FAAH (0.35) | — | |
| SCHEMBL2773691 | 0.80 | BRS3 (0.42) | BRS3 | |
| SCHEMBL2817023 | 0.79 | FAAH (0.56) | — | |
| SCHEMBL2809171 | 0.78 | FAAH (0.56) | — | |
| SCHEMBL2814405 | 0.78 | FAAH (0.51) | — | |
| SCHEMBL1471589 | 0.78 | FAAH (0.49) | — | |
| SCHEMBL2771966 | 0.78 | FAAH (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140045800-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-02-13 | — | — | US | disclosed |
| US-8372823-B2 | Tetracyclic inhibitors of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-02-12 | — | — | US | disclosed |
| EP-2152082-B1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | SCRIPPS RESEARCH INST (US) | 2012-08-29 | — | — | EP | disclosed |
| US-20100249078-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | THE SCRIPS RESEARCH INSTITUTE (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249078-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | FAAH, FAAH2, APEH | S1PR1 635/4885BRS3 1973/4885MMP12 353/4885 |
| US-20140045800-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | FAAH, FAAH2, APEH | S1PR1 635/4885BRS3 1973/4885MMP12 353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.