SCHEMBL28185019

SCHEMBL28185019

Nc1cccnc1.O=CC1CCNCC1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 8/20 0.42
CHRNA4 P43681 8/20 0.42
KDM1A O60341 1/20 0.39
CHRM2 P08172 1/20 0.38
CHRM1 P11229 1/20 0.38
CHRM3 P20309 1/20 0.38
CCNA2 P20248 1/20 0.38
CDK2 P24941 1/20 0.38
GABRA1 P14867 1/20 0.38
GABRG2 P18507 1/20 0.38
GABRB3 P28472 1/20 0.38
MKNK1 Q9BUB5 1/20 0.38
MKNK2 Q9HBH9 1/20 0.38
CHRNA7 P36544 3/20 0.36
CHRNA3 P32297 4/20 0.36
CHRNB4 P30926 3/20 0.36
CHRNA1 P02708 1/20 0.36
CHRNG P07510 1/20 0.36
CHRNB1 P11230 1/20 0.36
CHRND Q07001 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Piperazine SCHEMBL28208205 0.80 MEN1 (0.47) CHRNB2CHRNA4KDM1AMKNK1MKNK2
Formic Acid SCHEMBL27671743 0.73 MKNK1 (0.47) MKNK1MKNK2
Formic Acid SCHEMBL30444860 0.73 MKNK1 (0.47) MKNK1MKNK2
SCHEMBL19628 0.72
SCHEMBL29455057 0.72
SCHEMBL8482013 0.71 CHRNB2 (0.43) CHRNB2CHRNA4KDM1AGABRA1GABRG2
Formaldehyde SCHEMBL27300961 0.70 MEN1 (0.52) MKNK1MKNK2CHRNA7
Bromide SCHEMBL30665091 0.70
Hydrochloric Acid SCHEMBL3365191 0.70
Hydrochloric Acid SCHEMBL2867683 0.70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107417767-A Dipeptide compound, its preparation method and the application of piperidines or piperazine structure 杭州市西溪医院 2017-12-01 CN disclosed