Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5721994 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL3365191 | 1.00 | — | — | |
| SCHEMBL29455057 | 0.97 | — | — | |
| SCHEMBL19628 | 0.97 | — | — | |
| Bromide SCHEMBL27489538 | 0.94 | — | — | |
| Ammonia Solution, Strong SCHEMBL15387433 | 0.94 | — | — | |
| Bromide SCHEMBL30665091 | 0.94 | — | — | |
| SCHEMBL28202174 | 0.94 | — | — | |
| SCHEMBL28007338 | 0.94 | — | — | |
| Bromide SCHEMBL10383564 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104349775-B | Inhibitors of JAK1 and JAK2 | 伊莱利利公司 | 2017-06-06 | — | — | CN | claimed |
| CN-1977794-B | Composition comprising at least one 3-amino-pyrazolopyridine derivatives | OREAL | 2014-09-03 | — | — | CN | claimed |
| CN-1977794-A | Composition comprising at least one 3-amino-pyrazolopyridine derivatives | OREAL (FR) | 2007-06-13 | — | — | CN | claimed |
| CN-107257797-B | Use of azomethines bearing two pyrazolopyridine units for dyeing keratin fibres | 欧莱雅 | 2020-04-17 | — | — | CN | disclosed |
| CN-107074863-B | Process for the preparation of ATR kinase inhibitors and different solid forms thereof | 沃泰克斯药物股份有限公司 | 2019-12-03 | — | — | CN | disclosed |
| CN-107257797-A | Carrying the azomethine type compound of two Pyrazolopyridine units is used for the purposes of dyeing keratin fibres | 欧莱雅 | 2017-10-17 | — | — | CN | disclosed |
| CN-107105655-A | Probe for being imaged Huntington protein | CHDI基金会股份有限公司 | 2017-08-29 | — | — | CN | disclosed |
| CN-107074863-A | Radiolabeled derivatives of 2-amino-6-fluoro-N- [ 5-fluoro-pyridin-3-yl ] -pyrazolo [1,5-a ] pyrimidine-3-carboxamide compounds as ATR kinase inhibitors, processes for their preparation and their different solid forms | 沃泰克斯药物股份有限公司 | 2017-08-18 | — | — | CN | disclosed |
| CN-104349775-B | Inhibitors of JAK1 and JAK2 | 伊莱利利公司 | 2017-06-06 | — | — | CN | disclosed |
| CN-104066431-B | Pyrazine kinase inhibitors | 波托拉医药品公司 | 2017-03-08 | — | — | CN | disclosed |
| CN-102665718-B | Heterocyclic compounds useful as PDK1 inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2016-03-09 | — | — | CN | disclosed |
| CN-104349775-A | Inhibitors of JAK1 and JAK2 | LILLY CO ELI | 2015-02-11 | — | — | CN | disclosed |
| CN-104066431-A | Pyrazine kinase inhibitors | PORTOLA PHARM INC | 2014-09-24 | — | — | CN | disclosed |
| CN-1977794-B | Composition comprising at least one 3-amino-pyrazolopyridine derivatives | OREAL | 2014-09-03 | — | — | CN | disclosed |
| CN-102665718-A | Heterocyclic compounds useful as pdk1 inhibitors | BIOGEN IDEC INC | 2012-09-12 | — | — | CN | disclosed |
| EP-2230241-A1 | TETRAHYDRO-IMIDAZOÝ1,5-A¨PYRAZINE DERIVATIVES, PREPARATION METHODS AND MEDICAL USES THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2010-09-22 | — | — | EP | disclosed |
| CN-1977794-A | Composition comprising at least one 3-amino-pyrazolopyridine derivatives | OREAL (FR) | 2007-06-13 | — | — | CN | disclosed |
| EP-1392655-A2 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002062762-A2 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |