Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 4/20 | 0.48 |
| ▸ | IDO1 | P14902 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | HTR6 | P50406 | 2/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2818527 | 1.00 | CYP11B2 (0.48) | CYP11B2IDO1CA1CA2CA7 | |
| SCHEMBL2818681 | 0.83 | CYP11B2 (0.52) | CYP11B2IDO1TDO2 | |
| SCHEMBL2818872 | 0.83 | CYP11B2 (0.52) | CYP11B2IDO1TDO2 | |
| SCHEMBL2819320 | 0.83 | CYP11B2 (0.52) | CYP11B2IDO1TDO2 | |
| SCHEMBL2820667 | 0.79 | CYP11B2 (0.53) | CYP11B2IDO1KCNH2CYP11B1HTR6 | |
| SCHEMBL843195 | 0.73 | CYP11B2 (0.69) | CYP11B2IDO1TDO2 | |
| SCHEMBL2821046 | 0.72 | CYP11B2 (0.62) | CYP11B2IDO1TDO2KCNH2 | |
| SCHEMBL2822331 | 0.72 | CYP11B2 (0.62) | CYP11B2IDO1TDO2KCNH2 | |
| SCHEMBL2817749 | 0.72 | CYP11B2 (0.71) | CYP11B2IDO1TDO2KCNH2 | |
| SCHEMBL2817744 | 0.72 | CYP11B2 (0.71) | CYP11B2IDO1TDO2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8436035-B2 | Organic compounds | NOVARTIS AG (CH) | 2013-05-07 | — | — | US | disclosed |
| EP-2213668-A2 | Imidazoles as aldosterone synthase inhibitors | Novartis AG (CH) | 2010-08-04 | — | — | EP | disclosed |
| US-20100048562-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-02-25 | — | — | US | disclosed |
| CN-101605777-A | Imidazoles as aldosterone synthase inhibitors | NOVARTIS AG (CH) | 2009-12-16 | — | — | CN | disclosed |
| EP-2094680-A2 | IMIDAZOLES AS ALDOSTERONE SYNTHASE INHIBITORS | Novartis AG (CH) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008076336-A2 | IMIDAZOLES AS ALDOSTERONE SYNTHASE INHIBITORS | NOVARTIS AG (CH) | 2008-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048562-A1 | ORGANIC COMPOUNDS | CYP11B1, HSD11B1, CYP17A1 | CYP11B2 6/4885IDO1 1361/4885CA1 1469/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.