Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 5/20 | 0.48 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 4/20 | 0.37 |
| ▸ | CTSS | P25774 | 4/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2820849 | 0.92 | CHRM4 (0.47) | CHRM4TACR1P2RY12DPP4NPC1 | |
| SCHEMBL2817332 | 0.85 | CHRM4 (0.53) | CHRM4DRD2DRD3 | |
| SCHEMBL2818696 | 0.84 | CHRM4 (0.48) | CHRM4P2RY12DPP4NPC1DRD2 | |
| SCHEMBL2821338 | 0.83 | DRD2 (0.44) | CHRM4DPP4DRD2DRD3CTSL | |
| SCHEMBL13841884 | 0.83 | DRD2 (0.44) | CHRM4DPP4DRD2DRD3CTSL | |
| SCHEMBL2818171 | 0.83 | C5AR1 (0.44) | CHRM4DPP4DRD2DRD4GRM5 | |
| SCHEMBL2819005 | 0.82 | CHRM4 (0.43) | CHRM4TACR1DPP4NPC1CTSL | |
| SCHEMBL2821782 | 0.82 | DPP4 (0.45) | CHRM4DPP4DRD2DRD3DRD4 | |
| SCHEMBL2817206 | 0.81 | CHRM4 (0.42) | CHRM4DPP4DRD2DRD4GRM5 | |
| SCHEMBL3637803 | 0.81 | CHRM4 (0.42) | CHRM4DPP4DRD2DRD4GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155672-B1 | PROLINAMIDE DERIVATIVES AS NK3 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-10-27 | — | — | EP | claimed |