Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 6/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2820740 | 0.94 | CHRM4 (0.46) | CHRM4ALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL2818101 | 0.92 | CHRM4 (0.52) | CHRM4ALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL3638063 | 0.92 | CHRM4 (0.52) | CHRM4ALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL2819008 | 0.85 | CHRM4 (0.48) | CHRM4DRD2DRD3 | |
| SCHEMBL2818348 | 0.85 | CHRM4 (0.44) | CHRM4ALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL2818426 | 0.83 | CHRM4 (0.49) | CHRM4ALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL2817087 | 0.83 | CHRM4 (0.49) | CHRM4ALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL3638622 | 0.81 | CHRM4 (0.47) | CHRM4ALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL2817106 | 0.81 | CHRM4 (0.47) | CHRM4ALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL2817216 | 0.79 | SIGMAR1 (0.48) | SIGMAR1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155672-B1 | PROLINAMIDE DERIVATIVES AS NK3 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-10-27 | — | — | EP | claimed |