Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NNMT | P40261 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11222657 | 0.83 | SIRT6 (0.37) | MAPTCASP1SIRT6AURKATTK | |
| SCHEMBL13114213 | 0.82 | SIRT6 (0.39) | SIRT6PIK3CAFGFR1LMNANNMT | |
| SCHEMBL28004405 | 0.80 | SIRT6 (0.41) | MAPTSIRT6POLBTDP1NNMT | |
| SCHEMBL11216390 | 0.80 | CDK1 (0.40) | MAPTCCNA2CDK2CCNA1 | |
| SCHEMBL11217711 | 0.79 | ALDH1A1 (0.44) | MAPTCASP1HTTLMNA | |
| SCHEMBL1731975 | 0.78 | HTT (0.39) | MAPTCASP1AURKATTKAURKB | |
| SCHEMBL10314188 | 0.78 | SIRT6 (0.37) | SIRT6PIK3CAFGFR1LMNANNMT | |
| SCHEMBL29395867 | 0.78 | HTT (0.39) | MAPTCASP1AURKATTKAURKB | |
| SCHEMBL1731368 | 0.77 | CCR4 (0.38) | MAPTCASP1AURKATTKAURKB | |
| SCHEMBL1315972 | 0.77 | SIRT6 (0.36) | SIRT6HTTPIK3CAFGFR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107519168-A | A kind of application of NRF2 inhibitor and its related compound treatment tuberculosis infection | 中国医科大学 | 2017-12-29 | — | — | CN | disclosed |