Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 2/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.51 |
| ▸ | XDH | P47989 | 1/20 | 0.49 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.41 |
| ▸ | TOP1 | P11387 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2820201 | 0.88 | XDH (0.47) | MAPK13MAPK12MAPK11MAPK14XDH | |
| SCHEMBL2822421 | 0.85 | XDH (0.50) | XDHSLC22A12KMT2ABRAFLMNA | |
| SCHEMBL2824946 | 0.85 | XDH (0.48) | XDHSLC22A12KMT2AMAPTBRAF | |
| SCHEMBL2818647 | 0.83 | XDH (0.48) | XDHSLC22A12KMT2ABRAFRAB9A | |
| SCHEMBL2822721 | 0.83 | XDH (0.52) | XDHSLC22A12BRAFRAB9AALDH1A1 | |
| SCHEMBL2824998 | 0.83 | XDH (0.48) | XDHSLC22A12KMT2AMAPTTP53 | |
| SCHEMBL2819006 | 0.83 | XDH (0.48) | MAPK13MAPK12MAPK11MAPK14XDH | |
| SCHEMBL2818742 | 0.79 | SMO (0.58) | XDHSLC22A12KMT2AMAPTTP53 | |
| SCHEMBL4198997 | 0.71 | BRAF (0.72) | XDHSLC22A12BRAFFYN | |
| SCHEMBL4147232 | 0.70 | XDH (0.59) | XDHSLC22A12KMT2AMAPTBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1789044-B1 | PHENYLAMINOPYRIDINES AND PHENYLAMINOPYRAZINES | BASILEA PHARMACEUTICA AG (CH) | 2010-10-27 | — | — | EP | claimed |