⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14535150 | 0.83 | — | — | |
| SCHEMBL20393785 | 0.83 | — | — | |
| SCHEMBL13594472 | 0.83 | — | — | |
| SCHEMBL14469982 | 0.83 | — | — | |
| SCHEMBL18912897 | 0.83 | — | — | |
| SCHEMBL13914151 | 0.83 | — | — | |
| SCHEMBL5707761 | 0.76 | — | — | |
| SCHEMBL28150536 | 0.75 | PYGB (0.30) | — | |
| SCHEMBL7796924 | 0.75 | — | — | |
| SCHEMBL4436037 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104560997-B | Suppress siRNA compositions and its application of ADAMTS-5 and ADAM17 genes | 中国科学院广州生物医药与健康研究院 | 2018-05-04 | — | — | CN | disclosed |
| CN-107904239-A | Suppress siRNA and its application of 5 genes of ADAMTS | 广州市锐博生物科技有限公司 | 2018-04-13 | — | — | CN | disclosed |
| CN-104560999-B | siRNA for inhibiting ADAMTS-5 gene and application thereof | 广州市锐博生物科技有限公司 | 2018-01-09 | — | — | CN | disclosed |