Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29224574 | 0.82 | KDM4E (0.55) | KDM4EMAPTHIF1A | |
| SCHEMBL11243299 | 0.76 | ARG1 (0.54) | KDM4EMAPTHIF1ACYP2D6ALOX15 | |
| SCHEMBL11243295 | 0.76 | ARG1 (0.54) | KDM4EMAPTHIF1ACYP2D6ALOX15 | |
| SCHEMBL27692705 | 0.75 | KDM4E (0.42) | KDM4EMAPTHIF1ALMNASLC1A2 | |
| SCHEMBL4816295 | 0.72 | — | — | |
| SCHEMBL1841593 | 0.71 | FFAR4 (0.60) | — | |
| SCHEMBL15684283 | 0.71 | S1PR1 (0.50) | KDM4EMAPTHIF1ASLC1A2KEAP1 | |
| SCHEMBL2851779 | 0.71 | KDM4E (0.50) | KDM4EMAPTHIF1ARAB9AKEAP1 | |
| SCHEMBL2856431 | 0.71 | KDM4E (0.50) | KDM4EMAPTHIF1ARAB9AKEAP1 | |
| SCHEMBL31728258 | 0.71 | FFAR4 (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107406451-A | Pyrrolopyrimidines and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors | 福马治疗股份有限公司 | 2017-11-28 | — | — | CN | disclosed |