Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 5/20 | 0.58 |
| ▸ | KDR | P35968 | 8/20 | 0.56 |
| ▸ | RAF1 | P04049 | 6/20 | 0.56 |
| ▸ | BRAF | P15056 | 5/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.53 |
| ▸ | KIT | P10721 | 2/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.53 |
| ▸ | FLT3 | P36888 | 2/20 | 0.53 |
| ▸ | CA7 | P43166 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | CIT | O14578 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | MUSK | O15146 | 1/20 | 0.50 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL282309 | 0.95 | CDK8 (0.61) | CDK8KDRRAF1BRAFPDGFRB | |
| SCHEMBL282550 | 0.86 | CDK8 (0.61) | CDK8KDRRAF1BRAFTEK | |
| SCHEMBL719185 | 0.86 | HSD17B10 (0.48) | CDK8KDRPDGFRAFLT3ABL1 | |
| SCHEMBL281955 | 0.84 | RAF1 (0.55) | CDK8KDRRAF1BRAFTEK | |
| SCHEMBL282706 | 0.75 | KDR (0.61) | CDK8KDRRAF1BRAFPDGFRB | |
| SCHEMBL17360380 | 0.75 | NTRK1 (0.67) | CDK8KDRPDGFRBNTRK1 | |
| SCHEMBL282308 | 0.75 | CSF1R (0.70) | CDK8KDRRAF1BRAFPDGFRB | |
| SCHEMBL281916 | 0.75 | KDR (0.62) | CDK8KDRRAF1BRAFPDGFRB | |
| SCHEMBL28863201 | 0.74 | CDK8 (1.00) | CDK8KDRRAF1BRAFPDGFRB | |
| SCHEMBL281870 | 0.74 | KDR (0.69) | CDK8KDRRAF1BRAFPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428506-A1 | HETEROCYCLIC SUBSTITUTED ACARDITE DERIVATES AND USE THEREOF | Jiangsu Provincial Institute Of Materia Medica Co. (CN) | 2012-03-14 | — | — | EP | claimed |