Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.64 |
| ▸ | ALDH3A1 | P30838 | 5/20 | 0.64 |
| ▸ | ALDH2 | P05091 | 4/20 | 0.64 |
| ▸ | CES1 | P23141 | 6/20 | 0.63 |
| ▸ | BCHE | P06276 | 2/20 | 0.63 |
| ▸ | CDC25A | P30304 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | TGM2 | P21980 | 1/20 | 0.54 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11149709 | 0.91 | CES1 (0.67) | ALDH1A1ALDH3A1ALDH2CES1BCHE | |
| SCHEMBL902525 | 0.83 | MAOB (0.54) | ALDH1A1MEN1KMT2A | |
| SCHEMBL25119569 | 0.82 | CES1 (0.85) | ALDH1A1ALDH3A1ALDH2CES1BCHE | |
| SCHEMBL578329 | 0.81 | CES1 (0.71) | ALDH1A1ALDH3A1ALDH2CES1BCHE | |
| SCHEMBL25119255 | 0.81 | CES1 (0.84) | ALDH1A1ALDH3A1ALDH2CES1BCHE | |
| SCHEMBL3019788 | 0.80 | ALDH1A1 (0.90) | ALDH1A1ALDH3A1ALDH2CES1BCHE | |
| SCHEMBL28591995 | 0.80 | CES1 (0.81) | ALDH1A1ALDH3A1ALDH2CES1BCHE | |
| SCHEMBL10679114 | 0.79 | ALDH1A1 (0.64) | ALDH1A1ALDH3A1ALDH2CES1BCHE | |
| SCHEMBL19924204 | 0.79 | CES1 (1.00) | ALDH1A1ALDH3A1ALDH2CES1BCHE | |
| SCHEMBL281625 | 0.78 | ALDH1A1 (1.00) | ALDH1A1ALDH3A1ALDH2CES1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428515-A1 | Spiro-oxindole compounds and their uses as therapeutic agents | Xenon Pharmaceuticals Inc. (CA) | 2012-03-14 | — | — | EP | disclosed |
| EP-2073806-B1 | USE OF SPIRO-OXINDOLE COMPOUNDS AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC (CA) | 2012-02-15 | — | — | EP | disclosed |
| EP-1888595-B1 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC (CA) | 2012-02-01 | — | — | EP | disclosed |