SCHEMBL28196487

SCHEMBL28196487

CC(C)(C)c1ccc(C=O)c([N+](=O)[O-])c1C(C)(C)C

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.36
TDP1 Q9NUW8 2/20 0.36
TSHR P16473 1/20 0.36
SMN1; SMN2 Q16637 2/20 0.35
L3MBTL1 Q9Y468 2/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
GALR3 O60755 1/20 0.35
HTT P42858 1/20 0.35
ERN1 O75460 2/20 0.33
KDM4E B2RXH2 1/20 0.33
CYP3A4 P08684 1/20 0.33
MAPT P10636 1/20 0.33
ALOX15 P16050 1/20 0.33
PRKDC P78527 1/20 0.33
HSD17B10 Q99714 1/20 0.33
PTPN1 P18031 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18688898 0.76 SMN1; SMN2 (0.44) ALDH1A1TDP1TSHRSMN1; SMN2L3MBTL1
SCHEMBL180678 0.72 ERN1 (0.39) ALDH1A1TDP1TSHRMEN1KMT2A
SCHEMBL6903174 0.72 PTGS1 (0.32) TDP1MEN1KMT2A
SCHEMBL28021446 0.71 HPRT1 (0.44) ALDH1A1TDP1TSHRSMN1; SMN2L3MBTL1
SCHEMBL398817 0.70 ALDH1A1 (0.39) ALDH1A1TDP1TSHRSMN1; SMN2L3MBTL1
SCHEMBL28075565 0.70 HTT (0.54) ALDH1A1TDP1TSHRSMN1; SMN2L3MBTL1
SCHEMBL22712664 0.69 TDP1 (0.40) ALDH1A1TDP1TSHRSMN1; SMN2L3MBTL1
SCHEMBL8132797 0.69 CA1 (0.43) ALDH1A1TDP1TSHRL3MBTL1ERN1
SCHEMBL28188096 0.69 ERN1 (0.42) ALDH1A1TDP1TSHRMEN1KMT2A
SCHEMBL28155707 0.69 TDP1 (0.41) ALDH1A1TDP1TSHRMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107501099-A The adjusting control agent of ATP combination cassette transporters 沃泰克斯药物股份有限公司 2017-12-22 CN disclosed