Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Lidocaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN3A known ✓ | Q9NY46 | 3/20 | 0.85 |
| ▸ | SCN4A known ✓ | P35499 | 1/20 | 0.85 |
| ▸ | SCN5A known ✓ | Q14524 | 1/20 | 0.85 |
| ▸ | SCN9A known ✓ | Q15858 | 1/20 | 0.85 |
| ▸ | SCN1A known ✓ | P35498 | 2/20 | 0.50 |
| ▸ | SCN2A known ✓ | Q99250 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.85 |
| ▸ | MAPT | P10636 | 3/20 | 0.85 |
| ▸ | LMNA | P02545 | 3/20 | 0.85 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.85 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.85 |
| ▸ | MC4R | P32245 | 1/20 | 0.85 |
| ▸ | MC3R | P41968 | 1/20 | 0.85 |
| ▸ | HTR3A | P46098 | 1/20 | 0.85 |
| ▸ | GAA | P10253 | 3/20 | 0.83 |
| ▸ | BLM | P54132 | 2/20 | 0.83 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 7/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lidocaine SCHEMBL8183082 | 0.92 | MAPT (1.00) | ALDH1A1MAPTLMNASCN3ACYP3A4 | |
| Lidocaine SCHEMBL5334354 | 0.92 | MAPT (1.00) | ALDH1A1MAPTLMNASCN3ACYP3A4 | |
| Lidocaine SCHEMBL15689 | 0.92 | MAPT (1.00) | ALDH1A1MAPTLMNASCN3ACYP3A4 | |
| Lidocaine SCHEMBL3123623 | 0.91 | MAPT (0.91) | ALDH1A1MAPTLMNASCN3ACYP3A4 | |
| Lidocaine SCHEMBL17422676 | 0.91 | MAPT (0.97) | ALDH1A1MAPTLMNASCN3ACYP3A4 | |
| Lidocaine SCHEMBL29130 | 0.91 | MAPT (1.00) | ALDH1A1MAPTLMNASCN3ACYP3A4 | |
| Lidocaine SCHEMBL31031037 | 0.91 | MAPT (0.97) | ALDH1A1MAPTLMNASCN3ACYP3A4 | |
| Lidocaine SCHEMBL14782152 | 0.91 | MAPT (0.97) | ALDH1A1MAPTLMNASCN3ACYP3A4 | |
| Lidocaine SCHEMBL3128504 | 0.91 | MAPT (0.97) | ALDH1A1MAPTLMNASCN3ACYP3A4 | |
| Lidocaine SCHEMBL8377228 | 0.91 | MAPT (0.97) | ALDH1A1MAPTLMNASCN3ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105294477-B | A kind of preparation method of lidocaine hydrochloride | 浙江汇能生物股份有限公司 | 2018-01-19 | — | — | CN | claimed |
| CN-105294477-B | A kind of preparation method of lidocaine hydrochloride | 浙江汇能生物股份有限公司 | 2018-01-19 | — | — | CN | disclosed |