Lidocaine

Lidocaine

SCHEMBL3128504

Br.CCN(CC)CC(=O)Nc1c(C)cccc1C

nearest known ligand 0.97

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A

The experimentally established mechanism targets of Lidocaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN3A known ✓ Q9NY46 3/20 0.97
SCN4A known ✓ P35499 1/20 0.97
SCN5A known ✓ Q14524 1/20 0.97
SCN9A known ✓ Q15858 1/20 0.97
SCN1A known ✓ P35498 2/20 0.55
SCN2A known ✓ Q99250 2/20 0.55
MAPT P10636 4/20 0.97
LMNA P02545 3/20 0.97
ALDH1A1 P00352 3/20 0.97
CYP3A4 P08684 1/20 0.97
MAPK1 P28482 1/20 0.97
MC4R P32245 1/20 0.97
MC3R P41968 1/20 0.97
HTR3A P46098 1/20 0.97
BLM P54132 2/20 0.94
GAA P10253 2/20 0.94
HPGD P15428 3/20 0.67
TSHR P16473 2/20 0.61
RAB9A P51151 1/20 0.61
MEN1 O00255 3/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lidocaine SCHEMBL5334354 0.98 MAPT (1.00) MAPTLMNASCN3AALDH1A1CYP3A4
Lidocaine SCHEMBL15689 0.98 MAPT (1.00) MAPTLMNASCN3AALDH1A1CYP3A4
Lidocaine SCHEMBL8183082 0.98 MAPT (1.00) MAPTLMNASCN3AALDH1A1CYP3A4
Lidocaine SCHEMBL8377228 0.97 MAPT (0.97) MAPTLMNASCN3AALDH1A1CYP3A4
Lidocaine SCHEMBL31031037 0.97 MAPT (0.97) MAPTLMNASCN3AALDH1A1CYP3A4
Lidocaine SCHEMBL13726485 0.97 MAPT (0.97) MAPTLMNASCN3AALDH1A1CYP3A4
Lidocaine SCHEMBL17422676 0.97 MAPT (0.97) MAPTLMNASCN3AALDH1A1CYP3A4
Lidocaine SCHEMBL29130 0.97 MAPT (1.00) MAPTLMNASCN3AALDH1A1CYP3A4
Lidocaine SCHEMBL14782152 0.97 MAPT (0.97) MAPTLMNASCN3AALDH1A1CYP3A4
Lidocaine SCHEMBL27840048 0.97 MAPT (0.97) MAPTLMNASCN3AALDH1A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024137447-A1 BUFFERED LIDOCAINE INJECTABLE FORMULATIONS AND METHODS FOR MAKING SAME HIKMA PHARMACEUTICALS USA INC. (US) 2024-06-27 WO claimed
US-20240197621-A1 Buffered Lidocaine Injectable Formulations and Methods for Making Same HIKMA PHARMACEUTICLAS USA INC. 2024-06-20 US claimed
WO-2024137447-A1 BUFFERED LIDOCAINE INJECTABLE FORMULATIONS AND METHODS FOR MAKING SAME HIKMA PHARMACEUTICALS USA INC. (US) 2024-06-27 WO disclosed
US-20240197621-A1 Buffered Lidocaine Injectable Formulations and Methods for Making Same HIKMA PHARMACEUTICLAS USA INC. 2024-06-20 US disclosed
US-20230049330-A1 USE OF QX314 TO PREVENT SYMPATHOEXCITATION ASSOCIATED WITH ADMINISTRATION OF TRPV1 MODULATORS WELLSMART TECHNOLOGIES INC. 2023-02-16 US disclosed
EP-4114372-A1 USE OF QX314 TO PREVENT SYMPATHOEXCITATION ASSOCIATED WITH ADMINISTRATION OF TRPV1 MODULATORS Neucures, Inc. (US) 2023-01-11 EP disclosed
CN-115243683-A Use of QX314 to prevent sympathetic excitation associated with administration of TRPV1 modulators 纽克尔斯有限公司 2022-10-25 CN disclosed
CN-113396139-A Aryl amide compound based on benzene ring supermolecule interaction, self-assembly form and application 易天奇 2021-09-14 CN disclosed
WO-2021178471-A1 USE OF QX314 TO PREVENT SYMPATHOEXCITATION ASSOCIATED WITH ADMINISTRATION OF TRPV1 MODULATORS NEUCURES, INC. (US) 2021-09-10 WO disclosed
WO-2021142577-A1 ARYLAMIDE COMPOUND BASED ON BENZENE RING SUPRAMOLECULAR INTERACTION, SELF-ASSEMBLY MORPHOLOGY, AND USE 易天奇 2021-07-22 WO disclosed
EP-2203192-A1 WOUND CARE FORMULATION Northern Health And Social Care Trust (GB) 2010-07-07 EP disclosed
WO-2009037500-A1 WOUND CARE FORMULATION NORTHERN HEALTH AND SOCIAL CARE TRUST (GB) 2009-03-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230049330-A1 USE OF QX314 TO PREVENT SYMPATHOEXCITATION ASSOCIATED WITH ADMINISTRATION OF TRPV1 MODULATORS TRPV1, TRPV4, TRPV3 SCN3A 54/4885SCN4A 68/4885SCN5A 148/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.