Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 8/20 | 0.35 |
| ▸ | BACE1 | P56817 | 8/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 8/20 | 0.35 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.34 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7903380 | 0.92 | PROKR1 (0.39) | PROKR1CNR2PSMB5TSHR | |
| SCHEMBL2790786 | 0.90 | PROKR1 (0.44) | PROKR1CNR2CYP1A2MEN1KMT2A | |
| SCHEMBL2790497 | 0.90 | PROKR1 (0.45) | PROKR1CNR2KMT2ATSHRALDH1A1 | |
| SCHEMBL2789452 | 0.90 | PROKR1 (0.45) | PROKR1CNR2KMT2ATSHRALDH1A1 | |
| SCHEMBL2789222 | 0.88 | PROKR1 (0.41) | PROKR1CNR2CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL742501 | 0.87 | MAPT (0.43) | CYP2D6ALDH1A1 | |
| SCHEMBL742502 | 0.87 | MAPT (0.43) | CYP2D6ALDH1A1 | |
| SCHEMBL2877866 | 0.85 | PROKR1 (0.40) | PROKR1CNR2CYP1A2MEN1KMT2A | |
| SCHEMBL2789132 | 0.84 | PROKR1 (0.38) | PROKR1CNR2MEN1KMT2A | |
| SCHEMBL2788887 | 0.83 | PROKR1 (0.39) | PROKR1CNR2KMT2ATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |