Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 3/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PER2 | O15055 | 1/20 | 0.36 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.36 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2789452 | 0.93 | PROKR1 (0.45) | PROKR1CNR2HTR4CYP3A4KCNH2 | |
| SCHEMBL2790497 | 0.93 | PROKR1 (0.45) | PROKR1CNR2HTR4CYP3A4KCNH2 | |
| SCHEMBL7899697 | 0.92 | PROKR1 (0.39) | PROKR1CNR2FPR2HTR4CYP3A4 | |
| SCHEMBL2877866 | 0.89 | PROKR1 (0.40) | PROKR1CNR2FPR2HTR4CYP3A4 | |
| SCHEMBL2791623 | 0.89 | FPR2 (0.34) | PROKR1CNR2FPR2CYP3A4ITGB3 | |
| SCHEMBL2789132 | 0.88 | PROKR1 (0.38) | PROKR1CNR2FPR2HTR4CYP3A4 | |
| SCHEMBL2819819 | 0.88 | PROKR1 (0.41) | PROKR1CNR2ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL2788887 | 0.88 | PROKR1 (0.39) | PROKR1CNR2HTR4CYP3A4KCNH2 | |
| SCHEMBL2791612 | 0.85 | PROKR1 (0.39) | PROKR1CNR2FPR2CYP3A4ITGB3 | |
| SCHEMBL2817635 | 0.85 | PROKR1 (0.39) | PROKR1CNR2FPR2CYP3A4ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |